Micro-organisms: Viruses Flashcards

1
Q

What does it mean for a virus to be ‘obligate’?

A

An organism that fails to reproduce without exploiting a suitable host.

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2
Q

What is important about viral components during replication?

A

They must be able to self assemble.

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3
Q

What is a nucleocapsid?

A

Protein cage that helps form the viral particle genome contained within a protein capsule

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4
Q

What is a virion?

A

The infective viral particle.

For non-enveloped viruses this is the nucleocapsid; for enveloped viruses, this is the nucleocapsid and the envelope.

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5
Q

What does ‘H’ stand for with regard to viral naming?

A

Hemagglutinin receptor recognition on host cell

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6
Q

What are the characteristics of norovirus?

A

Non-enveloped (naked)

Self-limiting

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7
Q

What is important to note about naked viruses in comparison to enveloped ones?

A

They are much more stable in the face of environmental stress (e.g. gut, poor water treatment) than enveloped viruses.
Spread more easily

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8
Q

What is important to note about enveloped viruses in comparison to naked ones?

A

Must stay wet to remain infectious

Can spread via budding rather than cell lysis

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9
Q

How are different viruses grouped?

A
Single stranded
Double stranded
DNA
RNA
DNA and RNA
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10
Q

What are retroviruses?

A

Single stranded RNA viruses

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11
Q

What are hepadnaviruses?

A

Double stranded DNA viruses

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12
Q

What classes of proteins do the viral genomes code for?

A

Proteins for the future viral particles
Enzymes for genome replication
Proteins to interfere with host response

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13
Q

What is the site of viral entry into a host cell?

A

Site formed by the receptor and co-receptor

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14
Q

What are examples of -strand RNA viruses?

A
Influenza
Mumps
Measles
Rabies
Ebola
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15
Q

What are examples of double stranded RNA viruses?

A

Rotavirus

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16
Q

What are examples of + strand RNA viruses?

A

Poliovirus
Dengue
Hepatitis C

17
Q

What are examples of DNA viruses?

A

Adenovirus
Herpes
Ebstein-Barr

18
Q

How can a virus turn a host cell into a cancer cell?

A

Viral oncogene introduction

Insertion of viral DNA into host genome -> activation of host cell oncogenes

19
Q

Why are viral infections prevalent?

A
High mutagenic rates
Error prone polymerases
Recombination of viruses
Re-emerging infectious diseases
Latent/ persistent infections are prevalent