B4 Haematopoesis Flashcards
What is spectrin?
A cytoskeleton that forms a scaffold maintaining the integrity and shape of the RBC membrane
What is ankyrin?
A protein responsible for anchoring in channels to spectrin skeleton of RBC
What is a band 4.1 protein?
A protein with a key role in regulating membrane stability
What is a band 3 protein?
A protein responsible for exchanging chloride and bicarbonate ions across RBC membranes.
What is another term for a band 3 protein?
Anion Exchanger 1
How does band 4.1 protein work?
Stabilises spectin-actin cytoskeleton interactions which form the RBC membrane skeleton.
What can band 4.1 protein mutations lead to?
Anaemia and spherocytosis
What protein has a key role in CO2 uptake by RBCs?
Band 3 protein
How much of the cell membrane surface does band 3 protein take up?
25%
How many new RBCs are made in the bone marrow per second?
2.4 X 10 to the power of 6
How long is the life span of RBCs?
100-200 days
What is the role of macrophages in the spleen?
Removal of damaged red blood cells
What growth factor mediates erythropoesis?
Erythropoietin -EPO
How to RBCs principally derive energy?
The metabolism of glucose to lactate
What are the key features of RBCs?
Biconcave shape
No nucleus
Contain Hb
Why do people with specific blood types reject other blood types?
They have antibodies against all the other blood types (excluding group O)
