Methods of Spread (Neoplasia)

Question 1

methods of spreading neoplasia

Answer 1

• local invasion + extension

- seeding within body cavities

Question 2

seeding

Answer 2

cells drop into body cavity and land on other organs (distant spread; no longer local)

Question 3

metastasis

Answer 3

• distant spread via lymph and/or blood

- spread of CA from prim to secondary site

Question 4

most common secondary site of metastasis

Answer 4

lymphatic tissues

Question 5

1st stage metastasis

Answer 5

• local invasion aided by Es
• emboli enter blood or lymph vessel
• poor cell survival

Question 6

2nd stage metastasis

Answer 6

• distribution
• reach area of resistance
• attachment & growth @ secondary site by cytokines , gfs

Question 7

3rd stage metastasis

Answer 7

• proliferation with angiogenesis (dev of new blood vessels)