Hypertension (cardiovascular disorders) Flashcards

1
Q

hypertension (HTN)

A
  • when body unable to return BP to normal range

- persistently elevated BP (>140/90mmHg)

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2
Q

systole

A

pressure during pumping phase

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3
Q

diastole

A

pressure during filling phase

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4
Q

4 control mechanisms to monitor BP

A
  • baroreceptors
  • vascular autoregulation
  • renin-angiotensis-aldosterone system (RAAS)
  • fluid volume regulation
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5
Q

baroreceptors

A
  • detect change in BP –> send info to nervous system –> homeostatic mechanisms return pressure to normal (via vasodilation/constriction)
  • in tunica externa/adventitia of blood vessels
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6
Q

vascular autoregulation

A
  • blood vessels constrict and dilate

- happens in response to changes in body

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7
Q

RAAS

A
  • homeostatic mechanism triggered by dec in BP –> inc BP to normal (vasoconstrictor)
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8
Q

fluid volume regulation

A
  • kidneys excrete/retain fluid to maintain blood vol and BP

- operates tgt w/ RAAS

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9
Q

primary hypertension

A
  • idiopathic
  • 90% of HTN cases
  • one of the 4 control mechanisms defected, dont know which one
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10
Q

secondary hypertension

A
  • cause known

- usually renovascular problem (dec renal perf –> RAAS)

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11
Q

systolic HTN

A
  • elevated systolic pressure
  • inc prevalence after age 50
  • as we age, tissue degenerates –> inc PR in vessels d/t atherosclerotic change
  • change in elasticity –> atheromas form
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12
Q

white coat HTN

A

pt has HTN in healthcare setting. when outside healthcare setting, BP normal

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13
Q

malignant HTN

A
  • does not refer to cancer
  • acute scenario where diastolic pressure exceeds 120
  • emergency situation
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14
Q

gestational HTN

A
  • during pregnancy

- return to normal BP post-delivery (most)

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15
Q

mnfts of HTN

A
  • “silent killer”
  • initial mnfts = elevated BP
  • later mnfts = fatigue, palpitations, blurred vision, morning headaches, dizziness
  • can result in multi-organ failure
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16
Q

nonpharmacological Tx of HTN

A
  • lifestyle modifications (ex. DASH diet, exercise, weight control, reduce alcohol and smoking)
17
Q

pharmacological Tx of HTN

A
  • diuretics (promote diuresis) (1st line Tx)
  • Ca channel blocker (dec muscle contractions –> vasodilation + dec HR)
  • angiotensin II receptor blocker (vasodilation)
  • ACE inhibitor (cannot convert angiotensin I –> II so no vasoconstriction)