Hashimoto's Thyroiditis (hypothyroidism)

Question 1

hypothyroidism

Answer 1

• primary: thyroid –> 95% of hypothyroidism
• secondary: pituitary
• tertiary: hypothalamus
• etiology: autoimmunity or iatrogenic (radiation and Sx for hyperfx –> hypofx)

Question 2

Hashimoto’s Thyroiditis

Answer 2

• autoimmunity targeting gland (Ab + T cells) –> inflm
• antithyroid Abs block TSH binding (produced d/t autoimmunity)
• lymphocyte infiltrates destroy gland and induce atrophy of gland –> fibrosis
• approx 90% are middle aged women

Question 3

mnfts of Hashimonot’s Thyroiditis

Answer 3

• hypometabolic state
• myxedema (mucoid secretion in dermis of skin –> swelling of skin –> waxy appearance)
• cold sensitivity (d/t less heat production)
• fatigue (d/t less ATP production)
• dec CO
• dec CNS Fx
• weak muscle action
• inc weight (not metabolizing nutrients –> put into storage)

Question 4

Tx of Hashimoto’s Thyroiditis

Answer 4

• replacement therapy (T4 daily) –> ex. Synthroid