Metastatic Bone Tumours Flashcards
Cancers which usually metastasize to bone?
Breast Prostate Lung Renal cell Thyroid
Mean Survival of breast carcinoma with bony mets?
24-26 months
What are blastic lesions?
Lesions which fill the bone with extra cells
What are lytic lesions?
Lesions which destroy bone material
What type of mets come from breast carcinoma?
Blastic (sclerotic)
Lytic mets
What kind of mets come from prostate carcinoma?
Sclerotic mets
What type of mets come from lung carcinoma?
Lytic bony mets
Mean survival for lung carcinoma with bone mets?
6 months
Type of mets associated with renal cell carcinoma?
Large, very vascular lytic ‘blow out’ bony mets
Treatment of single bone mets with primary renal cell tumour?
Amenable to resection
Uncommon types of cancer with bone mets?
Adenocarcinoma of the colon, bladder cancer, melanoma
Bones most frequently involved in bone mets?
Vertebra Pelvis Ribs Skull Humerus Long bones of upper limb
Symptoms of bone mets?
- Pain may be initially misdiagnosed as a muscle strain
- Any pain with red flags should be investigated with an x-ray
- Pathological fracture
Investigations for metastatic bone tumours?
Breast exam
PR exam
CXR- pulmonary lesion
Blood tests: serum calcium (hypercalcaemia), LFTs, Plasma protein electrophoresis (myeloma), FBC, U&E
Treatment of impending pathological fracture?
Skeletal stabilization/ joint replacement
