Large Cell Vasculitis Flashcards

1
Q

what is it?

A

primary vasculitis which causes granulomatous inflammation predominantly of aorta and its major branches

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2
Q

what is the difference TA and GCA?

A

differ in age of onset, and GCA mainly occurs in temporal arteries

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3
Q

how do they present?

A

early features are non-specific, low-grade fever, malaise, night sweats, weight loss, arthralgia, fatigue claudicant symptoms in upper and lower limbs if untreated - vascular stenosis and aneurysm can occur - reduced pulses - bruits

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4
Q

how is it investigated?

A

CPR, PV/ESR elevated MR angiography: detect thickened vessel walls and stenosis

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