Lymphoid Structures and Lymphoctes EC Flashcards
What occurs in the lymph node follicle? What is the difference between a primary and secondary follicle?
B-cell localization and proliferation
Primary follicles dense and dormant
Secondary follicles active with pale germinal centers
What occurs in the paracortex? When would this area be enlarged?
House T-Cells
Enlarged in extreme cellular immune response (ie virus)
would NOT be enlarged in DiGeorge (no thymus)
Lymph node drainage of the upper limb and lateral breast
Axillary nodes
Lymph node drainage of Stomach
Celiac nodes
Lymph node drainage of Duodenum and Jejunum
Superior mesenteric nodes
Lymph node drainage of Sigmoid colon
Colic then Inferior mesenteric nodes
Lymph node drainage of Rectum and Anal canal (above pectinate line)
Internal iliac nodes
Lymph node drainage of Anal canal below pectinate line
Superficial inguinal nodes
Lymph drainage of testes
Para-aortic nodes
Lymph drainage of scrotum
Superficial inguinal nodes
Lymph drainage of thigh
Superficial inguinal nodes
Lymph drainage of lateral dorsum of foot
Popiteal nodes
What does the Right lymphatic duct drain?
Right arm
Right chest
Right half of face
What does the thoracic duct train? Where does it drain?
All but R-arm, R-chest, and R-face
Drains at junction of Subclavian and Internal Jugular veins
Does lymphatic blockage result in pitting or non-pitting edema?
Non-pitting edema (filled with protein, fat, etc.)
Within the spleen, where are T-Cells found?
PALS (periarterial lymphatic sheath)
Within the spleen, where are B-Cells found?
In follicles
What is the function of macrophages within the spleen?
To remove encapsulated bacteria
“Even Some Killers Have Nice Shiny Bodies”
E. coli Strep. pneumoniae Klebsiella pneumoniae H. influenzae Neisseria meningitidis Salmonella B Strep
What findings are their post-splenectomy?
Howell-Jolly bodies (RBC nuclear remnants)
Target cells
Thrombocytosis (increased platelets)
Thymus appearance and selection that takes place in each region
Cortex is DENSE with IMMATURE T-Cells
~Positive Selection (MHC restriction)
Medulla is PALE with MATURE T-Cells
~Negative Selection (Nonreactive to self)
What are M cells?
Present in gut
Present antigens from gut to Lymphocytes
Innate Immune System
Nonspecific - No memory
PMNs, Macrophages, Dendritic Cells, NK cells, Complement
Adaptive Immune System
Receptors that recognize pathogen undergo V(D)J recombination during development
Response slow at first exposure, but fast and robust with memory
T-Cells, B-Cells and circulating antibody
MCH I
HLA-A, HLA-B, HLA-C
Binds TCR and CD8
Express on ALL NUCLEATED CELLS (ie not RBCs)
Antigen loaded into ER (intracellular peptides)
Viral immunity
