Ch3 Laboratory findings in inflammation EC

Question 1

Neutrophilic leukocytosis

Answer 1

Cytokine release of postmitotic neutrophils from bone marrow

Question 2

Left-shifted smear

Answer 2

Increase band PMNs (>10%) in peripheral blood

Question 3

Toxic granulation

Answer 3

Dark blue/purple primary granules in PMNs

Due to abnormality in maturation of granules

Question 4

Dohle bodies

Answer 4

Gray-blue inclusions in PMNs

Accompanies toxic granulation

Question 5

Lab findings in chronic inflammation

Answer 5

Monocytosis and increased IgG

Question 6

Corticosteroids effect in blood:

Answer 6

Increased PMNs (inhibit integrins)
Decreased lymphocytes (induce apoptosis)

Question 7

ESR

Answer 7

Rate of settling of RBCs

Increased with plasma factors (rouleau formation)

Question 8

C-Reactive Protein (CRP)

Answer 8

Marker of necrosis and disease activity

Question 9

Serum protein electrophoresis in acute inflammation

Answer 9

Decreased albumin (due to increased synthesis of acute phase reactants)
No alteration in gamma-globulin peak

Question 10

Serum protein electrophoresis in chronic inflammation

Answer 10

Decreased albumin

Polyclonal gammopathy due to increased synthesis of IgG