Important Cytokines and Cell Surface Markers EC

Question 1

IL1-IL5 Functions

Answer 1

"Hot T-BONE stEAk"
IL-1=fever
IL-2=T cell proliferation
IL-3=Bone marrow stimulation
IL-4=IgE production
IL-5=IgA production

Question 2

IL-1

Answer 2

Pyrogen (causes fever)
Acute inflammation
Secreted by macrophages

Question 3

IL-2

Answer 3

Stimulate growth of T cells

Question 4

IL-3

Answer 4

Support growth of bone marrow

Question 5

IL-4

Answer 5

Induces Th2 differentiation

Promotes IgE glass switching

Question 6

IL-5

Answer 6

Promotes B cell differentiation

Promotes production of IgA (Eonsinophils)

Question 7

IL-6

Answer 7

Fever

Acute-phase protein

Question 8

IL-8

Answer 8

Chemotaxis of Neutrophils

Question 9

IL-10

Answer 9

Anti-inflammatory

Question 10

IL-12

Answer 10

Th1 differentiation

NK activation

Question 11

TNF-alpha

Answer 11

Septic shock

Leukocyte recruitment and vascular leak

Question 12

Interferon-gamma

Answer 12

Activates macrophages, Th1, and NK cells
Increases MHC expression
Suppres Th2

Question 13

What do Th1 cell secrete?

Answer 13

Interferron-gamma (activates macrophages, supresses Th2)

IL-2 (stimulate T-cells)
IL-3 (stimulate marrow)

Question 14

What do Th2 cells secrete?

Answer 14

IL-4 (IgE, Th2 differentiation)
IL-5 (IgA, eosinophils)
IL-10 (inhibits Th1)

IL-2 (stimulate T-cells)
IL-3 (stimulates marrow)

Question 15

Helper T cell markers

Answer 15

CD4, CD40L (CD4 only)

TCR, CD3, CD28 (all T cells)

Question 16

Cytotoxic T cell markers

Answer 16

CD8 (CD8 only)

TCR, CD3, CD28 (all T cells)

Question 17

B cell markers

Answer 17

Ig
CD19, CD20, CD21, CD40
MHCII, B7

Question 18

Macrophage cell markers

Answer 18

CD14, CD40
MHCI, B7
Fc and C3b receptors

Question 19

NK cell markers

Answer 19

CD56 (unique marker)

CD16 (binds Fc of IgG)