Lymph Nodes Flashcards
What is the pathway of lymph?
- afferent duct
- subcapsular sinus
- cortical/trabecular sinus
- medullary sinuses
- efferent duct
- next node
What does the lymph node do?
it filters lymph
What are sinuses inside lymph nodes?
vascular spaces filled with lymph
What is this?
Lymph node
What kind of immunological respose does the lymph node give?
specific immunological response
Why would a lymph node become swollen and tender?
due to infection or cancer
What is the trayectory of lymph inside a lymph node?
- Afferent vessel
- Subcapsular sinus
- Trabecular sinus
- Medullary sinus
- Efferent vessel
What are the divisions of the lymph node?
- Capsule
- Subcapsular sinus
- Cortex
- Paracortex
- Medulla
- Medullary cords
- Medullary sinuses
What does the subcapsular sinus have?
macrophages
What does the cortex of a lymph node contain?
B cells
What cells does the paracortex of a lymph node contain?
T cells
Identify the division of the lymph node (A,B,C)
A= capsule
B = Paracortex
C = MEdula
True or False
Efferent lymphatic vessels penetrate the capsule, dumping lymph into the sinus where its contents are processed by lymphocytes and APCs
False - Afferent lymphatic vessels are the ones that penetrate the capsule
Through where do macrophages migrate after they have phagocytosed an antigen to reach the T cells? To what layer do they migrate?
To where do T cells migrate after macrophages have presented them with the antigen? Why?
- Trabecular sinuses
- To the paracortex
- They migrate to the cortex
- To stimulate B cells so that they create germinal centers
Where is the paracortex?
between the cortex and the medulla
What does the paracortex contain?
Contains high endothelial venules that permit T cells to exit the bloodstream and enter the lymph node
What does the medulla have to hold plasma cells?
medullary cords that contain reticular framework
What do plasma cells secrete into the medullary sinuses?
antibodies
What are high endothelial venules?
permit T cells to exit the bloodstream and enter the lymph node
they also express addressins
what are addressins?
they specify the particular lymph node
Through where can T cells leave the lymph node?
Trabecular sinus and medullary sinus to flow through the efferent vessels
What mechanism is used by T cells to leave the lymph node?
Diapedesis
What molecules are used by T cells to exit the vasculature?
They use L-selectin to slow down and roll and then use selectin to exit the vasculature
What is this?
High endothelial cells
