Lec 9 Hemoglobin Gas Transport

Question 1

a protein with a heme prosthetic group

Answer 1

hemoglobin

Question 2

solubility of oxygen increases in the blood via

Answer 2

hemoglobin

Question 3

globin is a blank

Answer 3

protein

Question 4

heme is a blank group of the hemoglobin

Answer 4

prosthetic

Question 5

two subunits of hemoglobin are blank while the other two are blank

Answer 5

alpha, beta

Question 6

hemoglobin has blank structure so it has blank

Answer 6

quaternary, allostery

Question 7

hemoglobin has all blank

Answer 7

alpha helices

Question 8

each globin has a blank

Answer 8

heme

Question 9

hemoglobin is a blankenzyme

Answer 9

holo

Question 10

1 molecule of Hb binds blank dioxygens

Answer 10

4

Question 11

hemoglobin is made of blank non identical alpha helices

Answer 11

8

Question 12

hemoglobin blank oxygen

Answer 12

transports

Question 13

blank stores oxygen

Answer 13

myoglobin

Question 14

blank has more oxygen

Answer 14

myoglobin

Question 15

oxygen is sandwiched between blank in hemoglobins

Answer 15

histidine

Question 16

hemoglobin will either be fully blank or blank

Answer 16

oxygenated, deoxygenated

Question 17

homotropic allosteric effect means same blank

Answer 17

ligand (like oxygen)

Question 18

homotropic and heterotropic allosteric effects can be either blank or blank

Answer 18

positive, negative

Question 19

oxygen blank binding of more oxygen

Answer 19

promotes

Question 20

2,3 BPG promotes blank of oxygen

Answer 20

dissociation

Question 21

myoglobin is a blank chain and does not have blank

Answer 21

single, quaternary strucutre

Question 22

myoglobin also supplies oxygen to blank but has a blank affinity

Answer 22

tissues, higher

Question 23

hemoglobin binds oxygen in the blank where the concentration is blank

Answer 23

lungs, high

Question 24

myoglobin binds oxygen in blank where concentration is blank

Answer 24

muscle, low (storage)

Question 25

decreased pH moves oxygen dissociation curve to the blank

Answer 25

right

Question 26

lower pH means blank oxygen in the tissue

Answer 26

less

Question 27

physiological adaptation where hemoglobin unloads oxygen more efficiently when there are increased protons

Answer 27

bohr effect

Question 28

2,3 bpg is a blank allosteric effector

Answer 28

negative heterotropic

Question 29

2,3 bpg is from blank in active tissues

Answer 29

glucose

Question 30

2,3 bpg moves oxygen dissociation curve blank

Answer 30

right

Question 31

fetal hemoglobin lacks the two blank subunits

Answer 31

beta

Question 32

fetal hemoglobin cannot bind blank

Answer 32

2,3 bpg

Question 33

negative heterotropic allosteric effector unlike oxygen

Answer 33

co2

Question 34

carbon dioxide, bicarbonate, and carbonic acid make up a blank system

Answer 34

buffer

Question 35

carbon dioxide is more blank than oxygen

Answer 35

soluble

Question 36

carbonic acid ionizes to form blank

Answer 36

bicarbonate

Question 37

more than blank percent of carbon dioxide is transported as bicarbonate

Answer 37

50

Question 38

enzyme that catalyzes the reaction of co2 and water

Answer 38

carbonic anhydrase

Question 39

when concentration of bicarbonate increases, blood pH blank, but excretion of CO2 compensates for increased blank to blank pH

Answer 39

falls, H+, raise

Question 40

co2 can react with hemoglobin to form carbamino compounds known as blank

Answer 40

carbamates

Question 41

carbamates help hemoglobin transport co2 to blank

Answer 41

lungs

Question 42

oxy form is the blank form

Answer 42

r

Question 43

deoxy form of hemoglobin is blank form

Answer 43

t

Question 44

as bicarbonate is transported out of RBC, blank ions enter the RBC to keep blank

Answer 44

chloride, electrical balance

Question 45

chloride shift that pumps bicarbonate out and chlroride in is a blank system

Answer 45

antiport

Question 46

chloride acts as a blank

Answer 46

buffer system

Question 47

O2 and CO2 transport are blank

Answer 47

integrated

Question 48

carbon monoxide is bound blank to hemoglobin

Answer 48

more tightly than oxygen

Question 49

HbS (sickle hemoglobin) has 2-4 more positive charges than HbA molecules

Answer 49

pauling

Question 50

heterozygotes of sickle cell anemia help guard against blank

Answer 50

malaria

Question 51

red blood cells deliver blank and remove blank from tissues

Answer 51

oxygen, co2