Block 3 - Lec 36 - Hemoglobin / Globin Genes

Question 1

functional human hemoglobins all contain blank of two dissimilar blank chains

Answer 1

tetramers, globin

Question 2

adult and fetal hemoglobin have blank alpha subunits

Answer 2

alpha

Question 3

embryonic hemoglobin have blank beta subunits

Answer 3

epsilon

Question 4

there are multiple blank for hemoglobin…. kind of like collagen

Answer 4

gene families

Question 5

at birth there is no blank hemoglobin

Answer 5

embryonic

Question 6

fetal hemoglobin goes away after about blank of life

Answer 6

1 year

Question 7

alpha globin family is on this chromosome

Answer 7

16

Question 8

beta gloin family is on this chromosome

Answer 8

11

Question 9

sickle cell anemia is caused by a blank mutation from a blank base change

Answer 9

missense, single

Question 10

Hb S is blank

Answer 10

sickle cell

Question 11

sickle cell is from blank replacing blank codon and a blank residue replacing a blank residue in the protein

Answer 11

GUG, GAG, valine, glutamate

Question 12

local anesthesia is blank for sickle cell patients

Answer 12

safe

Question 13

general anesthesia is blank for sickle cell patients

Answer 13

dangerous

Question 14

most hemoglobin variants are due to blank

Answer 14

single aa subsitutions (structural changes)

Question 15

another alteration in hemoglobin that has changed quantitative expression

Answer 15

thalassemias

Question 16

thalasemia is most common in blank population

Answer 16

mediterranean (greek, italian)

Question 17

individuals who carry a thalassemia gene fail to produce the normal quantity of one or more blank

Answer 17

globin chains

Question 18

most of the hemoglobin in adults (95%) is blank

Answer 18

Hb A

Question 19

two types of thalassemia and are insufficient produciton of these globins

Answer 19

alpha, beta

Question 20

more levels of thalassemia

Answer 20

1,2,3,4

Question 21

mild anemia no big deal

Answer 21

1

Question 22

anemia that can still live a normal life

Answer 22

2

Question 23

anemia that has excess beta globin and thus Hb H disease with a shorter lifespan

Answer 23

3

Question 24

anemia that is incompatible with life and results in dead fetus

Answer 24

4