Lec 5 - Fibrous Proteins

Question 1

fibrous proteins are the building blocks of blank

Answer 1

ct

Question 2

enzymes and adaptor proteins that are generally soluble or amphipathic

Answer 2

globular proteins

Question 3

massive structural proteins

Answer 3

fibrous proteins

Question 4

fibrous proteins are insolube and composed of blank units

Answer 4

repeating

Question 5

globular proteins have crosslinks that are all blank

Answer 5

disulfide bonds

Question 6

fibrous proteins have blank cross links

Answer 6

unique

Question 7

mutations in coding of collagen, elastin, and keratin causes blank

Answer 7

ct defects

Question 8

tendons, cartilage, dentin, bone has a lot of

Answer 8

collagen

Question 9

ligaments and artery walls have a lot of this fibrous protein

Answer 9

elastin

Question 10

hair, nails, and skin have this type of fibrous protein

Answer 10

keratin

Question 11

collagen makes up blank of the total protein in mammals

Answer 11

25-35%

Question 12

each chain of collagen has about blank amino acids

Answer 12

1000

Question 13

1/3 of all amino acids in collagen

Answer 13

glycine

Question 14

hemoglobin is globular and only has blank percent glycine

Answer 14

5

Question 15

percent of collagen that is proline

Answer 15

25%

Question 16

insuficient vitamin c

Answer 16

scurvy

Question 17

proline is typically in the blank conformation

Answer 17

trans

Question 18

proline blank movement

Answer 18

restricts

Question 19

collagens basic building block is the blank

Answer 19

polyproline helix

Question 20

proline is what geometrically imposes the shape of the blank

Answer 20

polyproline helix

Question 21

polyproline helix does not have any blank, instead shape is maintained by steric constraints

Answer 21

hydrogen bonds

Question 22

higher order structures of collagen does have blank even though it is made of polyproline helices

Answer 22

hydrogen bonding

Question 23

vitamin c is aka

Answer 23

ascorbic acid

Question 24

posttranslational modification must take place before formation of blank so the lysine and proline can be accessed by enzymes

Answer 24

triple helix

Question 25

triple helix formation needs blank to maximize hydrogen bonding

Answer 25

alignment

Question 26

after secretion, the propeptide sequences at the ends get in the way of blank

Answer 26

getting close together

Question 27

procollagen peptidases are used to blank

Answer 27

cleave off propeptide ends

Question 28

after a bunch of triple helix bundles are formed, they should be blank in order to form collagen cross links

Answer 28

staggered

Question 29

lysyl oxidase is a blank enzyme

Answer 29

copper

Question 30

cross links involve modification of 1 or 2 blank

Answer 30

lysines

Question 31

cross links can still be formed if lysine isnt there because there are blank mechanisms

Answer 31

several

Question 32

elastin structure looks kind of like this kind of globular protein structure

Answer 32

beta turn

Question 33

repeating units of blank forms the elastin spring

Answer 33

ValProGlyVal

Question 34

valine contributes to the blank of elastin

Answer 34

insolubility

Question 35

valine also limits the number of blank to make it easier to stretch out

Answer 35

hydrogen

Question 36

keratin is mainly for mechanical blank

Answer 36

stability

Question 37

keratin structure is blank

Answer 37

alpha helix

Question 38

keratin alpha helices are cross linked by blank and these are blank bonds and can be broken by blank

Answer 38

disulfide, covalent, reduction

Question 39

10% of residues in keratin may be blank

Answer 39

cysteine

Question 40

close packing of the helices also make it difficult for blank with reagents

Answer 40

breaking

Question 41

primary structure differences dictate differences in these structures and functions

Answer 41

secondary, quaternary