Lec 15 - TCA Cycle

Question 1

acetyl coA requires blank for formation

Answer 1

vitamin b5

Question 2

catabolism makes blank

Answer 2

atp

Question 3

acetyl coA has a blank function

Answer 3

dual

Question 4

tricarboxylic acid has three carboxyl groups and cremates blank

Answer 4

acetyl coA

Question 5

tca cycle uses acetyl coA to make these

Answer 5

nadh, fadd2, gtp

Question 6

citrate is used to make blank

Answer 6

fatty acid/cholesterol

Question 7

succinate is a blank signal

Answer 7

inflammatory

Question 8

1st step of tca

Answer 8

citrate synthase…. thioesterbond is important

Question 9

acetyl coA needs this for made in step 1

Answer 9

oxaloacetate

Question 10

step 2

Answer 10

aconitase… tertiary alcohol to secondary alcohol

Question 11

citrate is blank but aconitase is blank so when they interact as an enzyme-substrate they become blank

Answer 11

symmetrical, nonsymmetrical, non symmetrical

Question 12

step 3

Answer 12

isocitrate dehydrogenase… oxidative decarboxylation of secondary hydroxyl group and carboxyl group becomes CO2

Question 13

4th step

Answer 13

a-ketoglutarate dehydrogenase…. oxidative decarboxylation and makes thioester bond

Question 14

thioester bond is blank

Answer 14

high energy

Question 15

a-ketoglutarate dehydrogenase is similar to blank because it has e1, e2, e3 subunits and requires the same 5 cofactors

Answer 15

pdc

Question 16

alcoholism results in poor blank absorption which inhibits blank

Answer 16

b1, a-ketoacid dehydrogenase

Question 17

step 5

Answer 17

succinyl coA synthetase…. succinyl coA to succinate and gtp via substrate level phosphorylation

Question 18

phosphofructokinase blank atp

Answer 18

consumes

Question 19

gtp is converted to atp via blank

Answer 19

NDK

Question 20

step 6

Answer 20

succinate dehydrogenase (component of ETC)… succinate oxidized to fumerate

Question 21

step 7

Answer 21

fumerase…. fumerate hydrated to malate

Question 22

step 8

Answer 22

malate dehydrogenase…malate to oxaloacetate

Question 23

in the tca cycle there is no net gain of blank

Answer 23

oxaloacetate (consumed by first…. produced by last)

Question 24

look at delta G’s

Answer 24

ok

Question 25

trace carbons

Answer 25

ok

Question 26

negative delta G reactions of TCA cycle are easy targets for blank

Answer 26

regulation

Question 27

thermodynamic barrier can be gotten past in the last reaction of tca cycle by decreasing the concentration of blank to drive it in the forward direction

Answer 27

oxaloacetate

Question 28

complete oxidation of glucose gives blank atp

Answer 28

38

Question 29

blank atp are produced by tca cycle alone

Answer 29

24

Question 30

6 carbon turns to 3 carbon via

Answer 30

glycolysis

Question 31

glycerol phosphate shuttle changes nadh to blank

Answer 31

fadh2