Lec 13 - Glycolysis Flashcards
mutant protein kinase results in a damaged blank which leads to blank resistance
rbc, malaria
glut 1,2,3,4 are all blank transport during fed state into low conc intracellularly
passive
glut 3,4 have a low blank
Km (high affinity)
brain uses blank percent of energy and blank percent of total carb intake
20%, 75%
transporter that brain and placenta and testis use
glut 3
transporter in erythrocytes
glut 1
liver, beta cells, small intestine, kidney have this
glut 2
muscle and adipose tissues have blank
glut 4
small intestine has blank
glut 5
glut 4 is for blank speed
high
glut 2 is for blank
sensing/making adjustements/linear
glut 4 is regulated by blank
insulin
glut 4 only uses glucose in the blank state
fed
type 2 diabetes which is insulin resistance damages machinery of blank
glut 4
glucose transport and blank are coupled
phosphorylation
positive feedback regulator in highly regulated
fructose 1,6 biphosphate
most important glycolysis step
3
9 steps of glycolysis
Hexokinase/glucokinase, phosphoglucoisomerase, pfk-1, aldolase, phosphoglucoisomerase, gapdh, phosphoglycerate kinase, phosphoglycerate mutase, enolase, pyruvate kinase, lactate dehydrogenase
reactions 1-5 of glycolysis do blank
energy consumption (2 atp)
reactions 6-10 are blank phase
energy production
net energy yield of glycolysis that includes oxygen
8
anaerobic net glycolysis atp production
2 atp
most important steps of glycolysis
3, 6
defective pyruvate kinase leads to impaired blank
glycolysis
