Lec 41

Question 1

Unicellular eukaryotes like yeast only ask

Answer 1

Is the cell large enough when regulating the cell cycle

Question 2

G1-cyclines regulated by

Unicellular eukaryotes

Answer 2

Inhibitor proteins whose amount is fixed

Question 3

Regulating human cell cycle

Answer 3

The question is should the cell reproduce

Question 4

Liver cells are in

Answer 4

G0 temporarily

Question 5

Neurons are in

Answer 5

G0 permanently

Question 6

Mitogens

Answer 6

Control cell that controls reproduction

Regulates synthesis of G1 Cyclins

Question 7

Most mitogens are also

Answer 7

Growth factors

regulate amount and activity of ribosomes

can be positive or negative

Question 8

Positive mitogen

Answer 8

PDGF

positive mitogen/growth factor

Question 9

Blood vessel damage releases

Answer 9

PDGF which is a platelet cell

Question 10

PDGF signals

Answer 10

Fibroblasts to reproduce and make collagen which repairs blood vessel damage

Question 11

Platelet cell and fibroblasts signaling is

Answer 11

Paracrine

Question 12

DNA damage

Answer 12

cell cycle is halted after DNA cycle by inhibiting

G1-Cdk, S-Cdk, and M-Cdk

Question 13

p53

Answer 13

is a positive transcription factor

Regulated at the level of protein stability

Question 14

p53

moderate DNA damage

Answer 14

turns on p21 gene

Question 15

p21 gene

Answer 15

inhibits cyclin-Cdks

halts cell cycle

Question 16

p53 indirectly

Answer 16

fixes DNA damage

turns on DNA repair enzyme genes to fix DNA

Question 17

p53 indirectly turns on

during sever damage

Answer 17

Apoptosis through PUMA gene