Lec 36 Flashcards
Estradiol site of origin
Ovary
Estradiol (estrogen)
Chemical nature
Steroid (derivative of cholesterol)
Estrogen actions
Induces and maintain secondary female chracteristics
Steroid hormones are
Hydrophobic molecules
Made from cholesterol
Globulin proteins
Carry steroid hormones in circulatory system
Steroid hormone receptors
Intracellular receptors (inside the cell)
Nuclear receptor protein binds to hormone after it crosses the membrane
Transcription factors
steroid hormones
Receptor hormone complex binds to regulatory region of target gene and activates transcription
Estrogen is a
Category
Estradiol is a
Specific molecule
Androgens is a
Category
Testosterone is a
Specific molecule
Purpose of estrogen signaling
Sex determination of females
Mammalian embryo step 1
Uncommitted gonad is turned into a ovary or teste by sexual transcription factors
Mammalian embryo step 2
Ovaries and testes make sex hormones
Mammalian embryo step 3
Sex hormones travel to other cells