Lec 36 Flashcards

1
Q

Estradiol site of origin

A

Ovary

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2
Q

Estradiol (estrogen)

Chemical nature

A

Steroid (derivative of cholesterol)

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3
Q

Estrogen actions

A

Induces and maintain secondary female chracteristics

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4
Q

Steroid hormones are

A

Hydrophobic molecules

Made from cholesterol

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5
Q

Globulin proteins

A

Carry steroid hormones in circulatory system

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6
Q

Steroid hormone receptors

A

Intracellular receptors (inside the cell)

Nuclear receptor protein binds to hormone after it crosses the membrane

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7
Q

Transcription factors

steroid hormones

A

Receptor hormone complex binds to regulatory region of target gene and activates transcription

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8
Q

Estrogen is a

A

Category

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9
Q

Estradiol is a

A

Specific molecule

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10
Q

Androgens is a

A

Category

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11
Q

Testosterone is a

A

Specific molecule

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12
Q

Purpose of estrogen signaling

A

Sex determination of females

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13
Q

Mammalian embryo step 1

A

Uncommitted gonad is turned into a ovary or teste by sexual transcription factors

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14
Q

Mammalian embryo step 2

A

Ovaries and testes make sex hormones

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15
Q

Mammalian embryo step 3

A

Sex hormones travel to other cells

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16
Q

Target cells of these sex hormones

A

Are both estrogen and androgen receptors because they do not know which cell they are going to receive

17
Q

Mammalian embryo step 4

A

Sex hormones are delivered on carrier proteins

18
Q

Mammalian embryo step 5

A

Sex hormones bind to its associated receptor and enter the complex enters the nucleus and activates a specific effect to that gender

19
Q

Estrogen is delivered by

A

SHBG which also delivers testosterone

20
Q

Medical significance of estrogen

A

High level of estrogen indicates pregnancy

21
Q

Birth control pills

A

Increases estrogen to make the body think it is pregnant and prevent the release of oocytes

22
Q

Too many estrogen receptors can cause

A

Cancer