Lec 39 Flashcards by Rasul Taghizada

Q

Cell cycle checkpoints

A

G1

M

G2

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Q

Cyclin-Cdk complex

A

Kinases phosphorylate target proteins

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Q

Phosphatases are present in

A

Low numbers but always present

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Q

Cyclin dependent kinases
Cdks

A

Always at a high level (acting during cell cycle)

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Q

Cyclins

A

Bind to Cdks and dictate their targets

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Q

G1 cyclins

A

Prep for DNA replication

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Q

S cyclins

A

Start DNA replications

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Q

M cyclins

A

Start prophase (mitosis)C

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Q

Cyclin makes Cdk

A

Active

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Q

Cyclin amount

A

Cycles from low to high

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Q

G1 Cdk means

A

Cdk with cyclin in G1

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Q

G1 Cdk has

A

2 targets

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Q

S Cdk has

A

2 targets

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Q

M cdk has

A

6 targets

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Q

Cyclin A binds to

A

Cdk2 and moves the T loop which exposes the active site and allows it to bind to targets

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Q

Anaphase promoting complex (APC)

A

Triggers anaphase

Adds Ubiquitin rather than phosphates

2 targets

Q

after attaching ubiquitins

polyubiquinated proteins are broken down by

A

Proteasomes

Q

G1 Cdk is activated by

A

G1 checkpoint

Q

S cdk is activated by

A

beginning of s phase

Q

M-cdk is activated by

A

beginning of mitosis

Q

APC is activated

A

At the end of metaphse