L14: Adaptive Recognitionn Flashcards
Which cells make up the adaptive immunity
T cells
B cells
What are the receptors of T cells called
T cell receptor
What are the receptors of the B cells called
B cell receptor
What 2 chains are the B cell receptors made of
Heavy
Light
What are the types of light chain in B cell receptors
Kappa
Lambda
What are the 2 regions in a B cell receptor
Fab domain
Fc domain
Which domain is variable
Fab domain
What is the fab domain made of
Heavy chain
Light chain
What is the fc domain made of
Heavy chain
What bond joins the heavy and light chains together in the B cell receptors
Disulphide bonds
In the B cell and T cell receptors where does the antigen bind to
Antigen binding site
How many antigen binding sites are there in the T cell receptor
1
How many antigen binding sites are there in the B cell receptor
2
What chains are present in the T cell receptor
Alpha (similar to light chain in BCR)
Beta (similar to heavy chain in BCR)
What gene segments do heavy chains have
V
D
J
C
What gene segments do light chains have
V
J
C
What gene segments do alpha chain have
V
J
C
What gene segments do beta chains have
V
J
D
C
On what chromosome is light chains expressed on
Chromosome 22 and 2
On what chromosome is heavy chain expressed on
14
On what chromosome is TCR alpha chains expressed on
14
On what chain is TCR beta chain expressed on
7
For B cell receptors which chain is rearranged first
Heavy chain then light chain
On T cell receptors which chain is rearranged first
Beta chain then alpha chain
Which enzyme carries out gene rearrangement
RAG
Which enzyme does point mutations
TdT enzyme
Which receptor can become secreted
B cell receptor
When B cell receptor is secreted what is it known as
Immunoglobulin/antibody
Can B cell receptors recognise the pathogen/antigen directly
Yes
Can T cell receptors recognise the pathogen/antigen directly
No
If the T cell receptors cannot recognise the antigen/pathogen directly what binds to the antigen binding site of it
MHC
What are the classes of MHC
Class 1
Class 2
Which T cell does MHC class 1 bind to
CD8 T cells
Which T cells does MHC class 2 bind to
CD4 T cell
What type of protein does MHC class 1 present
Endogenous
What type of protein does MHC class 2 present
Exogenous
Which cells express MHC class 1
Every cell apart from RBC
Which cells can express MHC class 2
Lymphoid cells
