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Stuff I Get Wrong > JEFFREY BEZOS > Flashcards

JEFFREY BEZOS Flashcards

1
Q

down’s syndrome caused by nondisjunction occurs during what meiosis phase?

A

Meiosis 1

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2
Q

the ovarian artery, vein, lyphatics are located where?

A

in the suspensory ligameent of the ovaria (infundibulopelvic L.)

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3
Q

injury to the sacral spinal nerves could cause what?

A

distal colon stool retention, fecal inconitnence, weak sphingter

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4
Q

all mycoplasma species lack what?

A

peptidoglycan cell wall

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5
Q

testicular germ cell tumors which secrete____ can cause gynceomastia by what mechanims?

A

hcg

impaired testosterone production and increased aromitization of leydig cells

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6
Q

remember that exudates will have high

A

protein or LDH

not triglycerides (chylothorax transudates could tho)

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7
Q

the deficency in AIP is

as a result, ___ can be upregulated, espeically with CYP inducers, ETOH, or smoking, which causes the abdominal pain and other sx

Treatment is ___

A

Porphobilinogen deaminase

ALA synthetase

glucose or hemin which inhibit ALA synthetase atviy, reducing sx

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8
Q

what is the moa of Ziduvodine

A

NRTI

thymidine analogue lacking 3’ OH group causing chain termiantion

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9
Q

ehich TB drug causes optic neuropathy?

A

EThambutol

EFFECts the EYES

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10
Q

tap protines involved in

A

MCH1

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11
Q

positive s100 and HMB45 means

A

melanoma

s100 is on cells from NCC lineage (including melanocytes)

there are 100s of melanocytes in melanoma

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12
Q

persitent bronchial dilation aka ___ is asox with ___

A

bronchiectasis

kartagner syndrome (not pancreatic insuff which is CF)

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13
Q

overexpression of HER2 is more/less aggressive than ER+ or PR+?

A

More aggressive, tx with trazuuzumab

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14
Q

5a reductase inhibitors do what? (finasteride)

A

decrease conversion of T to DHT, therefore build up of T, less DHT and increase in estradiol

(estradiol increases because extra T gets converted to E)

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15
Q

arginine is a precursor to what?

A

NO

also CRT and UREA

(CUN)

BH4 is required cofactor to make NO

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16
Q

enterococcus can cause

A

endocarditis after GU rpocedures

UTIs

wound infections

grows in 6.5% NaCl and bile

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17
Q

licthinase (alpha toxin) in C. perfringens does what?

A

degrades lecithin, part of the phospholipid bilyaer leading to membrane damage, death and necrosis

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18
Q

large AV fistulas can cause what?

which cause what?

A

decreased SVR

increasd CO and increasd venous return

eventually heart can’t kepe up and heart faulure results

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19
Q

what is the major pathogenic contributor to a fib?

A

atrial remodeling

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20
Q

what are two major risk factors of prolonged EPO use?

A

HTN and thromboembolism

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21
Q

what is reactive thrombocytosis?

A

most common cause of elevated PLT in any age group

high levels of IL6

seen in chronic infection, burns, rheumatologic dz, hemolysis and iron def

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22
Q

glioblastoma multiforme

A
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23
Q

Tdt+, youth, mediastinal mass, lots of circulating lymhoblasts

A

ALL

24
Q

PSGN will have decreased C3 or C4?

A

C3 decreased

C3PO-PSGN

25
Q

helpful chart on nephrotic syndrome

A
26
Q

which cells form the atheroma, macrophages or smooth muscle?

A

smooth muscle

27
Q

do you need a slit lamp to see keiser fiecher rigns?

A

yes aparantly

28
Q

in chronic lung graft rejection, what will be seen on patholog?

A

bronchilitis oblitertans

29
Q

what changes are seen post-orchiectomy?

A

initial drop in T so Leydig cells stimulate LH and testosterone normalizes

Sperm count may still be low

30
Q

prolonged QRS can be seen with

A

class IC antiarrythmics (flecainade)

31
Q

what is the most commmon cause of elevated AFP?

A

dating errors, tf?

32
Q

Left HF can lead to pulmonary edema causing what?

A

lungs are stiff and heavy and compliance decreases

33
Q

thiazides cause accumulation of Ca where?

A

in the blood

not the urine, hence why it helps avoid calcium stones becaue Ca in urine makes stones, CA in blood does not make stones

34
Q

help

A
35
Q

exclusively breast fed infants need what?

A

vit D

babys need size D breasts

36
Q

epinephrine effects

A
37
Q

nephrotic syndrome is ___ state?

A

hypercoaguable

loss of antithrombin III and other anticoagulant factors is responsible for the thrombic outcomes of neprhotic syndrome

38
Q

what kills people from lightening, burns or arrhythmias

A

arrhytmias smart ass

39
Q

h pylori where can lead to duodenal uclers

A

gastric antrum

40
Q

what homrones use zinc fingers?

A

thyroid, steroid, ADEK

41
Q

order of stabbs

A
42
Q

painful tender firm uterus with vaginal bleeding and no hx of c/s

A

placental abrutpiont

if hx of c/s and sketchy fetal HS probably uterine rupture

43
Q

what is a common electorlyte aberation of TMP SMX?

A

hyperkalemia

44
Q

HY CO poisoning

A
45
Q

high altitude sickness

A
46
Q

does demyleination decrease lenght (space) constant or temporal summation?dec

A

decreases length constant (in MS)

47
Q

sorbitol is converted to

A

fructose

48
Q

acellular pink material in alveoli

A

pulmonary edema

49
Q

what cells line a glial scar?

A

astrocytes

50
Q

what abortive drug acts as a partia progesterone agonist in pregnancty

A

mifeprostone

51
Q

mesotheliomas stain positive for

A

cytokeratins and maybe calretinin

52
Q

mtDNA dz effect family members differently becayse if

A

heteroplasmy

53
Q

what is the round mass made of in pyloric stenosis?

A

smooth muscle proliferation

54
Q

draw this

A
55
Q
A

Stuff I Get Wrong (34 decks)

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