Getting Dirty with Dirty Medicine Flashcards

1
Q

which HLA with MS?

A

HLA DR2

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2
Q

HLa DR3 is assox with what?

A

SLE

goodpastures

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3
Q

HLA DR4

A

RA and DM1

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4
Q

HLA DR7 is assox with what?

A

nephrotic syndrome

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5
Q

HLA b8 assox wit what?

A

MG and Graves

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6
Q

Ulcerative colitis is assox with what findings?

A

inflammation of the intra and extrahepatic bile ducts

primary sclerosing cholangitis

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7
Q

which conditions are assox with BOTH UC and Chrons ?

A

ankylosing spondylitis

sacroillitis

uveitis

erythema nodosum

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8
Q

extrophitic papillary carcinoma of the bladder is assox with which carcingoen?

A

naphtalymine (aniline dye)

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9
Q

nitrosamines (smoked meat) are assox with which cancer?

arsenic (metalloid in cig smoke) assox with which cancers?

vinyl chloride (PVC) assox with which cancer?

aflatoxin (aspergillus toxin) assox ith which cacner?

A

stomach cancer

SCC and angiosarcoma of the lvier

angiocarcinoma of the liver

hepatocelluar carcnoma

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10
Q

unilateral renal agenesis

A

developmental failure of the ureteric bud and metanephric mesenchyme

RET defect, AD

APLASIA

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11
Q

IN GENERAL, across all age groups, what is the most common cause of mengiitis

A

strep oneumo

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12
Q

hy dirty med

A
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13
Q

what type of casts do you see in the urine of someone abusing cocaine?

A

RBC casts due to hypertensice urgency/emergency

HTN in the stem is like 190sustolic

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14
Q

hy casts

A
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15
Q

testicular pain HY

A
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16
Q

kidney stone shapes

A
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17
Q

stones and assoxiations

A
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18
Q

HY associations

A
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19
Q

which immunosuppresent can cause gingival hyperplasia?

A

cyclosporine

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20
Q

drug MOAS

A
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21
Q

AE of immunospurepsents

A
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22
Q

seziure meds AE

A
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23
Q

where is the tail of the pancras?

A

splenorenal ligament

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24
Q

parvo uses what receptor?

A

red blood cell p antigen

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25
contraction alkalosis
loss in fluids RAAS activated PCT-bicarb reabsorp, Na retention, H loss CD-K excrecretion pH increases
26
straw or slightly blood nipple discharge
intraducrtal papilloma benign polypoide epithelial tumor in the lactiferous ducts
27
HY pagets of breat
28
phyllodes HY
29
DCIS HY
30
fobroadenoma hy
31
DELIRUM IN OLD PEOPLE FROM UTIS DUE TO WHAT NTM?
ACH
32
hy pscyh
33
NF1 mutation causing lisch nodules looks like wahT?
34
papilledema
35
keiser flescher rings
wilsoms
36
other hy eye
37
48hrs after mi a risk for
fibrinous pericarditis
38
hy mi
39
histology/phatophys post-mi
40
more hy post mi
41
aminoglycosides and se
nephrotox
42
drug moas
43
Se for TMP SMX
44
AE of tetra
45
chloramphenocol hy se
46
se of macrolides
47
hy drug 1
48
hy drug 2
49
in anti phospholipid antibody syndrome, what is the autoantibodies targeting?
autoantibodies against platelet membranes
50
antiphosphplopid ab syndrome (SLE with cardiolipin ab)
51
b9 vs b12 def
52
hy pathwyas
53
describe pagets disease of bone?
imbalance between osteoblast and osteoclast bone pain, hats fit tighter elevated ALKP assox with high output cardiac failrue
54
osteomalacia
55
osteopetrosis
kids thick fracture prone bone
56
erythema nodusom can come from what fungus?
coccidiomycosis
57
obsucre causes of coccidiomycoses
58
therapeutic index
these drugs are widly lethal theophyline digoxin warfarin lithium
59
drug ae hy
60
amyloid in the thyroid means what mutation?
Men 2a/2b medullary carcinoma of the thyroid
61
thyroid cancer mutations
62
key words for diff thyroid cancers
63
cell connections
64
hypothalamus
65
more hypothalammus
66
sturge webber
sporadic inheritance soomatic mutation in GNAQ (which should stabilize capillary web) port wine stain on face, leptimemnigral angioma, episclera hemangiooma seizures, IDD, early glaucoma (WEBber-capillary web issue)
67
tuberous sclerosis
AD gene in TSC1 cr 9 and TSC2 cr 16 (tumor supr genes) make hamertin and tuberin ash leaf spots, shagreen patch, cardiac rhadomyoma, renal angiomylolipoma, ungal fibroma, adenoma sebaceoum ONLY ONE with rhabdoMyoma and angioMYOlipoma lots of Muscle for TUBAs
68
VHL disease
AD deletion of VHL on cr 3 (tumor spr gene) overgrowth of protien bilateral RCC, pheochromocytoma hemangioblastoma and angioomas von HARP lindo H-hemangioblastoma A-angioma R-RCC P-pheochromocutomas
69
NF-1
AD gene NF-1 altered on cr 17 (tumor surp gene to inhibit ras) cafe au lait spots, neurofibromas, optic gliomas, lisch nodules (pigmented irs/hemartomas) axillary hyperpigmentation, pheochromocytomas, wilms tumor, scoilois, bone involvment
70
NF-2
AD NF2 gene (chr 22, tumor spr gene) merlin (scwhannin) bilateral acoustic shwanomma with tinnitus, sensoneural loss, facial apresis, facial parasthesias cerebellopontine angle epindymoma, meningioma, juvenile cataracts
71
hep B serology
acute infection: HBsAg and HBeAg infected hepatocytes: hbcag and makes anti-hbc (igm and igg) HBeAg goes away and HbeAb is made last ab is Anti-HBs goes up, HBsAg leaves
72
HBsAg HbEAg HbcAg Anti-HBc Anti-HbE Anti-HbS
acute or chronic-S for sick E-easily spread, replication/transmission core ag is useless, can't be detected previous or current infection, IgM-acute, IgG-chronic c-come across HpB low transmission, anti-E-anti-easily spread immune/recovery/vax-anti-Sick
73
awake alert awake tired
beta waves-busthing out work alpha waves-about to fall asleep
74
NonREM N1 N2 N3 REM
theta waves K complexes and sleep spindles delta waves beta waves (like being awake)
75
N1
theta lightest stage of sleep MYOCLON1C jerks 5/10% of total sleep
76
N2
k complex, sleep spindles bruxism 50% of sleep
77
N3
delta waves deepest sleep GH released 10-20% of sleep, decreases throughout the night
78
REM
beta atonic, immobile, autonimic increases (penile tumescence) boners with beta waves each phase 90-120min, 15%
79
n1 pathology N2 pathology N3 REM
OSA increases in N1 bruxissm sleep walking, night terrors, bedwetting, confused if woken MDD-decreases REm latency (go into REM faster), increased density and duration of REM
80
HMO
limited panel of physicians, required referrals from PCP, in network coverage
81
PPOs
out of network, not covered as well, more expensive, no referrals
82
EPO
same as HMO but smaller
83
POS
out of netowrk allowed but in network to reduce cost, recwuires referall, basically like a HMO and PPO mixed
84
capitation
docs receive a set amount per patient per time regardless of how much pt utilizies serrvices used by HMOs risk pool each cap is a set dollar amount
85
bundled payments
set amount per service divided by all providers based on health outcomes incentivised to improve patient outcome organization must pay for unexpected use or complications
86
fee for service
pt pays for each service volume over clinical outocme discounted fee for service-pt pays predetermined rate (PPO)