Heme/Onc Flashcards
What is diamond-blackfan anemia?
defect in erythropoeisis
increased HbF
macrocytic anemia with low reticulocytes
webbed neck, celt pallet, triphangeal thumbs
In AIP, what two substances accumulate?
ALA and porphobillinogen
What are the levels of PT, plasminogen and platlets like in DIC?
Low PLT
Low plasminogen
Prolonged PT
What chromosome is SCD associated with?
Cr 11
What is the MOA of Miraviroc?
Maraviroc is a fusion inhibitor that binds to CCR5 on the surface of T cells and monocytes to inhibit interaction with gp120on the HIV virus
What drug can be given for castration-resistant prostate cancer that is good for pain control and management of fractures?
Denosumab
What is the MOA of paclitaxel?
causes a hyperstabilization of polymerized microtubules, thereby preventing the breakdown of the mitotic spindle.
Which psych drug causes agranulocytosis?
Clozapine
In iron-deficient anemia, will there be anisocytosis or poiklocytosis?
anisocytosis (variety in size)
According to PERC rules, should you get a D-dimer or a CTA first?
CTA
Mycoplasma pneumoniae can cause cold-agglutins which is a (which type) hypersensitivity reaction?
type II
What is the bone marrow like in Acute Myeloid leukemia?
bone marrow in AML is hypercellular due to replacement of the normal cellular components of the marrow by blasts or blast equivalents and, thus, results in an associated anemia, lymphopenia, and thrombocytopenia
What drug and its MOA is a good treatment for preventing future TIAs?
(esp in a pt with GERD and ASA allergy>)
adenosine diphosphate (ADP) receptor blockers (clopidogrel)
What is the best treatment for PE esp in a pt with underlying renal failure?
what is the MOA?
unfractionated heparin. It potentiates binding of antithrombin III (AT-III), which inactivates the coagulation factors Xa and IIa (thrombin).
acute promyelocytic leukemia will have what findings?
Pancytopenia
possibly DIC
myeloblasts with red-staining intracytoplasmic inclusions
