IBD: Pharmacological Management

Question 1

IBD: Pharmacological Management

Answer 1

1. Aminosalicylate compounds
2. Oral or IV Corticosteroids
3. Immunosuppressive Drugs
4. Anti-diarrheal
5. Anti Tumor Necrosis Factor

Question 2

I: management for ulcerative colitis

Action: inhibits prostaglandin synthesis to reduce inflammation

Answer 2

Aminosalicylate Compounds

Sulfasalazine (Azulfidine)

Question 3

Aminosalicylate Compounds

Sulfasalazine (Azulfidine)

Adverse effects and client instructions

Answer 3

A/E:
1. Leukopenia
2. Anemia

CL:
1. take the drug with full glass of water
2. Take the drug PC to prevent GI discomfort

Question 4

I: reduce inflammation

Adverse effects:
1. Increased risk for infection
2. Hyperglycemia
3. PUD
4. Osteoporosis

Answer 4

Oral or IV Corticosteroids

Prednisone

Question 5

Oral or IV Corticosteroids

Adverse effects

Hint: IHOP

Answer 5

Increased risk for infection
Hyperglycemia
Osteoporosis
PUD

Question 6

Should be given in combination with steroids to be effective

I: to reduce inflammation

Answer 6

Immunosuppressive drugs

Cyclosporine, Mercaptopurine

Question 7

Immunosuppressive Drugs

Adverse effects

Hint: 3 -ia, RISHH

Answer 7

Anemia
Leukopenia
Thrombocytopenia
Renal failure
Infection
Stomatitis
Headache
Hepatotoxicity

Question 8

Anti-diarrheal drugs

Answer 8

1. Diphenoxylate HCL and Loperamide (imodium)

Question 9

Given for refractory disease or for toxic megacolon

An immunoglobulin G (IgG) that neutralizes activity of tumor necrosis factor

Answer 9

Anti Tumor Necrosis Factor

Infliximab (Remicade)