GERD: Pharmacological Management (p.2) Flashcards

1
Q

Calcium carbonate

Aluminum Hydroxide + Magnesium hydroxide + Simethicone

A

Antacid

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2
Q

Action: neutralizes acid

Therapeutic and Pharmacologic class: Antacid

A

Antacid

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3
Q

Key Nursing Considerations: Antacid

A

Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile

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4
Q

Famotidine
Cimetidine

A

Histamine 2 Receptor Antagonists

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5
Q

Action: decrease gastric acid production

Therapeutic class: antiulcer drugs
Pharmacologic class: H2RA

A

Histamine 2 Receptor Antagonists

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6
Q

Key Nursing Considerations: H2RA

A
  1. Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile
  2. For direct injection (IVP), dilute 2ml (20mg) with compatible solution to a total volume of either 5 or 10ml; administer over at least 2mins
  3. Monitor for QT-interval prolongation in patients with kidney injury
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7
Q

Metoclopramide

A

Prokinetic agents

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8
Q

Action: accelerates gastric emptying

Therapeutic class: GI stimulant

Pharmacologic class: Dopamine antagonist

A

Prokinetic Agents

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9
Q

Key Nursing Considerations: Prokinetic agents

A
  1. May cause tardive dyskinesia
  2. Typically used for short-term
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10
Q

Pantoprazole
Omeprazole
Esomeprazole
Lansoprazole

A

Proton Pump Inhibitors

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11
Q

Action: Decreases gastric acid production

Therapeutic class: Antiulcer agent

Pharmacologic class: Proton Pump Inhibitor

A

Proton Pump Inhibitor

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12
Q

Key Nursing Considerations: PPI

A
  1. Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile
  2. For a 2min infusion (IVP), give the reconstituted vials (4mg/ml) over at least 2mins
  3. May increase the risk of hip fractures and interfere with some vitamin and mineral absorption (B12, iron, magnesium)
  4. Interact with commonly prescribed medications such as diuretics and clopidrogel
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13
Q

Bethanechol chloride

A

Reflux inhibitor

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14
Q

Action: stimulates parasympathetic

Therapeutic and Pharmacologic class: Cholinergic

A

Reflux Inhibitor

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15
Q

Key Nursing Considerations: Reflux Inhibitor

A
  1. Primary use is for urinary retention
  2. Do not use with possible GI obstruction or peptic ulcer
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16
Q

Sucralfate

A

Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants

17
Q

Action: preserve mucosal barrier

Therapeutic class: antiulcer agents

Pharmacologic class: GI protectants

A

Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants

18
Q

Key Nursing Considerations: Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants

A
  1. Give on an empty stomach - either 1hr AC or 2hrs PC
  2. Separate from doses of antacid by 30mins
19
Q

Baclofen

A

Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)

20
Q

Action: reducing TLESRs to reduce reflux

Therapeutic class: muscle relaxant

Pharmacologic class: gamma-aminobutyric acid (GABA) agonist

A

Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)

21
Q

Key Nursing Considerations: Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)

A
  1. Only approved GABA-B agonist that reduces TLESRs
  2. Used when PPI therapy fails
22
Q

Antacid

Therapeutic and Pharmacologic class

23
Q

H2RA

Therapeutic class:
Pharmacologic class:

A

T: antiulcer
P: H2RA

24
Q

Prokinetic

Therapeutic class:
Pharmacologic class:

A

T: GI stimulant
P: Dopamine antagonist

25
Q

PPI

Therapeutic class:
Pharmacologic class:

A

T: Antiulcer drugs
P: PPI

26
Q

Reflux Inhibitors

Therapeutic class:
Pharmacologic class:

A

Cholinergic

27
Q

Surface agents/Alginate based barriers

Therapeutic class:
Pharmacologic class:

A

T: Antiulcer drugs
P: GI protectants

28
Q

Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)

Therapeutic class:
Pharmacologic class:

A

T: Muscle relaxant
P: Gamma-Butyric Acid (GABA) agonist