GERD: Pharmacological Management (p.2) Flashcards
Calcium carbonate
Aluminum Hydroxide + Magnesium hydroxide + Simethicone
Antacid
Action: neutralizes acid
Therapeutic and Pharmacologic class: Antacid
Antacid
Key Nursing Considerations: Antacid
Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile
Famotidine
Cimetidine
Histamine 2 Receptor Antagonists
Action: decrease gastric acid production
Therapeutic class: antiulcer drugs
Pharmacologic class: H2RA
Histamine 2 Receptor Antagonists
Key Nursing Considerations: H2RA
- Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile
- For direct injection (IVP), dilute 2ml (20mg) with compatible solution to a total volume of either 5 or 10ml; administer over at least 2mins
- Monitor for QT-interval prolongation in patients with kidney injury
Metoclopramide
Prokinetic agents
Action: accelerates gastric emptying
Therapeutic class: GI stimulant
Pharmacologic class: Dopamine antagonist
Prokinetic Agents
Key Nursing Considerations: Prokinetic agents
- May cause tardive dyskinesia
- Typically used for short-term
Pantoprazole
Omeprazole
Esomeprazole
Lansoprazole
Proton Pump Inhibitors
Action: Decreases gastric acid production
Therapeutic class: Antiulcer agent
Pharmacologic class: Proton Pump Inhibitor
Proton Pump Inhibitor
Key Nursing Considerations: PPI
- Potential risk of gastric acid suppression is the loss of protective flora and an increased risk of infection, especially Clostridium difficile
- For a 2min infusion (IVP), give the reconstituted vials (4mg/ml) over at least 2mins
- May increase the risk of hip fractures and interfere with some vitamin and mineral absorption (B12, iron, magnesium)
- Interact with commonly prescribed medications such as diuretics and clopidrogel
Bethanechol chloride
Reflux inhibitor
Action: stimulates parasympathetic
Therapeutic and Pharmacologic class: Cholinergic
Reflux Inhibitor
Key Nursing Considerations: Reflux Inhibitor
- Primary use is for urinary retention
- Do not use with possible GI obstruction or peptic ulcer
Sucralfate
Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants
Action: preserve mucosal barrier
Therapeutic class: antiulcer agents
Pharmacologic class: GI protectants
Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants
Key Nursing Considerations: Surface agents/Alginate based barriers
or
Mucosal Barrier Fortifiers/Protectants
- Give on an empty stomach - either 1hr AC or 2hrs PC
- Separate from doses of antacid by 30mins
Baclofen
Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)
Action: reducing TLESRs to reduce reflux
Therapeutic class: muscle relaxant
Pharmacologic class: gamma-aminobutyric acid (GABA) agonist
Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)
Key Nursing Considerations: Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)
- Only approved GABA-B agonist that reduces TLESRs
- Used when PPI therapy fails
Antacid
Therapeutic and Pharmacologic class
Antacid
H2RA
Therapeutic class:
Pharmacologic class:
T: antiulcer
P: H2RA
Prokinetic
Therapeutic class:
Pharmacologic class:
T: GI stimulant
P: Dopamine antagonist
PPI
Therapeutic class:
Pharmacologic class:
T: Antiulcer drugs
P: PPI
Reflux Inhibitors
Therapeutic class:
Pharmacologic class:
Cholinergic
Surface agents/Alginate based barriers
Therapeutic class:
Pharmacologic class:
T: Antiulcer drugs
P: GI protectants
Inhibitors of Transient Lower Esophageal Sphincter Relaxations (TLESRs)
Therapeutic class:
Pharmacologic class:
T: Muscle relaxant
P: Gamma-Butyric Acid (GABA) agonist