Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IHD Part 2 - BDS 3 > Human herpes virus > Flashcards

Human herpes virus Flashcards

1
Q

herpes virus structure

A
  • icosahedral capsid (protein nuclear capsid)
  • teguments links outer lipid bilayer and nuclear capsid
  • outer lipid bilayer has proteins which stick out, tend to be glycoproteins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

HHP classifications

A

1) alpha
- tend to affect epidermal and neuronal cells
2) beta
- T cells and leukocytes
- slow growth
3) gamma
- primarily B lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

diseases caused by herpes virus

A

oropharyngeal and genital herpes
chicken pox (varicella zoster virus)
EBV causes granular fever etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

infection and replication of herpes virus

A

Oral epithelial cell host receptor
- viral glycoproteins bind proteoglycans binds to specific cells
- once bound, uncoats, envelope goes and nuclear capsid translocated inside the cell
- capsid goes into the nucleus, sheds coat and then enters inside DNA , human polymerase transcribes/translates viral genes
- protiens placed on viral cell surface
- build up of viral particles in the cell
Excreted into cytoplasm
- cell burts, release virus into ECM to then bind again

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HSV

A

1
- mainly oral
infection primary hepatic gingivostomatits

2
mainly genital
reactivatio,
secodary infection herpes labials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what causes HSV reactivation

A

UV light
stress
illness
immunosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HSV 1

A 
now as herpetic gingivostomatitis
virus enters trigeminal sensory neurones
translocated up NS to trigeminal ganglion
remains latent until reacvated
goes to peripheral nerve entings
viral particules shed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

clinical features of herpetic gingivostomatitis

A 
drinking and eating painful (halitosis)
multiple oral vesicles
erythema
maliase
pyrexia
lympahdenopathy

investigations include viral culture or PCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PCR

A

denature DNA to singel strnas
annealing of specific primers to DNA
extension by polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

management of herpetic gingivostomatitis

A

acyclovir
fluids/soft diet
analgesics/antipyretics
local antisepctive e.g. chlorhexidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

how does acyclovir work

A

analogues of guanisie
more effective at phosphorylating nucleotides than human TK
ACV (False nucleotide) phosphorlayed by viral TK enzyme to ACV-P
ACV- P inhibits virus replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

herpes labialis features and treamtent

A

HSV 2

prodromal irritation
crusting lesions
vesicles at or near mucocutaneous junction of lips

acyclovir cream
OTC drying and antibacterial agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

herpetic Whitloq

A

infection of fingers from handling oral tissues of someone with active HP 1/2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

hsv encephalitis

A

adults HSV 1
headache and gever

HSV2 neonates
skin rash lesions
CNS symptoms
repsiraotry distress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HHV 3

A

viracella zoster
primary infection chicken pox
secondary herpes zoster shingles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how does HHV3 develop

A 
natural infection of nasopharynx
replication in regional lymph nodes
viral replication in host tissues
then clinical symptoms occur 
-  skin reach fever etc
17
Q

herpes zoster oral disease

A 
3 phases
1)	pre herpetic neuralgia
-	
2)	rash
-	
-
3)	post herpetic neuralgia
-
18
Q

pre herpetic neuralgia herpes zoster oral disease

A
  • pain in distribution of the affected division of the trigeminal nerve
  • prior to development of rash
19
Q

rash of herpes zoster oral disease

A
  • unilateral vesicles in the distribution of a branch of the trigeminal nerve
  • ophthalmic, maximally, mandibular
  • Vesicles break down to form 1- Ulcers (mucosa), crusting lesions (skin)
20
Q

post herpetic neuralgia herpes zoster oral disease

A
  • painful burning sensation in the distribution of the affected nerve
  • effective treatment of zoster may reduce risk of neuralgia
  • treat pain with tricyclic anti depressants and neuropathic pain drugs
21
Q

treatment of herpes zoster oral disease

A

acyclovir

analgesics

22
Q

EBV infection

A

primary
- EBV replicates in oroharyngeall epotelail cells
latency in B lymphocytes

23
Q

what is EBV associated with

A

infection mononucleosis (glandular fever)
burkitts lymphoma
nasopharyngeal carinoma

24
Q

where is HSV 8 found and can cuase

A

aids pts

kaposis sarcoma

IHD Part 2 - BDS 3 (55 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions