Genito urinary infections 2/ STI Flashcards
transmission of STI
- any form of sexual activity in which no barrier is used and exchange of fluid or contact with mucosal epithelium occurs
main STI organisms
neisseria gonorhoea chlamydia trachomatis treponema pallidum (syphilis) HIV geneital herpes Hep B
N gonorrhoeae and pathogenesis
never a commensal, usually a fully virulent human pathogen
1) surface pili- pil proteins
- attachment
2) opa proteins
- aid attachment
3) lipo- oligosaccharide
- sialyated – complement resistance- host mimicry
4) por proteins
- nucleate actin aiding cell invasion
5) possesses IgA protease
- aids survival inside host cells
what can N gonohoeae case
salpingitis
infection in fallopian tubes
sterilut
infant blindness
HIV and gohnohoeas
increases transmission of HIV 500%
vise vera 5%
diagnosis and treatment of gohnorrhoeae
urethral swab
chocolate agar
sugar fermentation test (glucose +)
oxidase +
ceftriazone, azithromycin
syphilis and types
incubation period 2-10 wks
primary lesion resolves spontaeously (proliferation of trep in lymph nodes)
secondary 6-8 weeks post infection
bacteria disseminate around body - flue like illness
latent syphilis
Tertiary syphilis - involves Cv sequalae
syphilis treatmetn and transmission
causes by treponema pallidum
penicillin long course
skin abrasion
vertical transmission cross placemtan (congenital shyphilis)
what causes genital warts
HPV
chlamydia
chlamydia trachomatis
damage to cells and immunopathology causing fibrosis and scarring
can also cause conjinctivitis
complications of chlamydia
chronic pelvis pain
ectopic pregnancy
infertility
other diseases associated with chlaymidai
proctitis reactive arthritus conjunctivitis trachoma neonates infecte during both
chlamydia trachomatis
small obligate intracellular parasite
gram -
small genome
restricted cell range (only grows in certain areas)
diagnosing chlaymidai and treamtent
culture
direct immunofluresnee and ELISA
PCR tests
treatment
azithromycin
doxycycline
