General pathology Flashcards
Epithelial cells derived from ectoderm, mesoderm, and endoderm
Germ layer origin of epithelial cells
Connective tissue derived from mesoderm
Germ layer origin of connective tissue
Muscular tissue derived from mesoderm
Germ layer origin of muscular tissue
Nervous tissue derived from ectoderm
Germ layer origin of nervous tissue
Type of tissue that covers and lines surfaces; consists of cells close to each other forming membranes or sheets
Epithelial tissue
Secretes substances; includes endocrine and exocrine types
Glands
Free surface of epithelial tissues
Apical surface
Motile structure seen in respiratory tract and fallopian tubes; sweeps materials
Cilia
Structure for absorption seen in epididymis and vas deferens
Stereocilia
Brush border/striated structure for absorption seen in the GIT
Microvilli
Characteristic of epithelial tissue; lacks blood supply and receives nutrients from connective tissue
Avascular
Locations include Bowman’s capsule, endothelium, loop of Henle, and lung alveoli
Simple squamous epithelium
Locations include ducts of glands, walls of thyroid follicles, and kidney tubules
Simple cuboidal epithelium
Non-ciliated type in gallbladder; ciliated type in uterine tubes
Simple columnar epithelium
Keratinized type in skin; non-keratinized type in vagina, esophagus, and cervix
Stratified squamous epithelium
Located in ducts of sweat glands
Stratified cuboidal epithelium
Found in male urethra
Stratified columnar epithelium
Found in urinary bladder
Transitional epithelium (urothelium)
Ciliated type in trachea; non-ciliated type in epididymis
Pseudostratified columnar epithelium
Examples include sweat glands and pyloric glands
Simple tubular glands
Example: Brunner glands
Compound tubular glands
Example: Littre glands
Simple acinar glands
Example: Lacrimal glands
Compound acinar glands
Example: Submandibular glands
Compound tubulo-acinar glands
Secretes without cytoplasmic loss; examples include goblet cells and sweat glands
Merocrine secretion
Secretion involves cytoplasmic loss; example: mammary glands
Apocrine secretion
Secretion involves complete breakdown of the cell; example: sebaceous glands
Holocrine secretion
Most abundant tissue type; varies in appearance and functions; binds, protects, and supports
Connective tissue
Type of connective tissue that is not vascularized
Cartilage (hyaline, elastic)
Components of connective tissue; includes extracellular matrix and ground substance
Extracellular matrix components
Fixed cells in connective tissue; includes fibroblasts and adipocytes
Fixed connective tissue cells
Type of connective tissue cells that include WBCs, RBCs, and macrophages
Wandering connective tissue cells
Fibers produced by fibroblasts; includes collagen, elastic, and reticular fibers
Connective tissue fibers
Most abundant connective tissue fiber
Collagen fiber
Connective tissue fiber known for elasticity
Elastic fiber
Connective tissue fiber that stains with silver
Reticular fiber
Tissue with varied appearance and functions; includes Dense Regular, Dense Irregular, Embryonic, Reticular, Elastic, Areolar
Connective tissue types
Bone with a compact (diaphysis) and spongy (epiphysis) structure, more organized in compact and less in spongy
Osseous (Bone)
Functional unit of bone tissue
Osteon
Adipose tissue with unilocular adipocytes
White adipose
Adipose tissue with multiocular adipocytes and increased mitochondria
Brown adipose
Muscle tissue with alternating striations, voluntary, cylindrical and multinucleated
Skeletal muscle
Muscle tissue with cylindrical and branching fibers, involuntary, and centrally located nucleus
Cardiac muscle
Muscle tissue that is non-striated, spindle-shaped, involuntary, with mitosis
Visceral/Smooth muscle
Tissue responsible for rapid communication; consists of neurons and neuroglia
Nervous tissue
Cell in nervous tissue that receives stimuli and conducts waves of excitability
Neuron
Neuroglia cells responsible for support, protection, and insulation
Neuroglia
Cell type that produces myelin in the CNS
Oligodendrocyte
Cell type that produces myelin in the PNS
Schwann cell
Cells in nervous tissue that support the blood-brain barrier
Astrocyte
Cells in nervous tissue that act as macrophages
Microglia
Process of tissue degeneration due to damage or disease
Pathobiology
Definition: non-appearance of an organ
Agenesis
Definition: failure of an organ to reach mature size
Hypoplasia
Definition: failure of an organ to form an opening
Atresia
Reduction in cell size and substance, could be physiologic or pathologic
Atrophy
Increase in cell size without new cells, e.g., muscle growth from exercise
Hypertrophy
Increase in cell number, leading to tissue enlargement, e.g., breast during pregnancy
Hyperplasia
Change of one cell type to another, reversible and adaptive, e.g., columnar to squamous in smokers
Metaplasia
Abnormal cell growth and differentiation, a pre-cancerous stage
Dysplasia
Undifferentiated cellular change, with features like pleomorphism and hyperchromatism, irreversible
Anaplasia