Functie van de lever en gevolgen, behandeling van cirrose Flashcards

1
Q

cirrose

A

is een onomkeerbaar proces van omzetting van levercellen naar littekenweefsel. Het is een eindstadium van een proces genaamd leverfibrose.

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2
Q

micronodulair

A

<3 mm, door alcohol

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3
Q

macronodulair

A

> 3mm

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4
Q

hepatitis

A

infectie (genezing/asymp drager), chronisch (stabiel), cirrose (gecomp, transplantatie), kanker

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5
Q

oorzaken lever cirrose

A

alcohol, virale hepatitis, NAFDL/NASH, drugs en toxines, biliaire obstructie, auto-immuun, idiopatisch, hemochromatose, Wilson’s ziekte

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6
Q

compensated lever cirrose

A

geen complicaties

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7
Q

decompenseerde lever cirrose

A

icterus, ascites, variceal bleeding, encelophatie, spontane bacteriele peritonitis, hepatorenaal syndroom en slechte voeding

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8
Q

klinische diagnose levercirrose

A

kan heel lang asymptomatisch zijn, geschiedenis, elevated LFRs, trombocytopenie
- hepatomegalie, jaundice, ascites, spider angioma, splenomegalie, palmar erythema, fetor hepaticus, purpura

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9
Q

flapping tremor

A

armen omhoog, hand naar achter > hand blijft niet in positie door verstoorde hersenfunctie

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10
Q

behandeling levercirrose

A

De behandeling is erop gericht om het proces van levercirrose af te remmen, symptomen te bestrijden en complicaties te vermijden

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11
Q

lever biopsie

A

oorzaak, activiteit

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12
Q

Hoe kun je biopsie afnemen

A

percutaan, transjugulair veneus, laproscopisch, open, plugged

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13
Q

Fibroscan

A

non invasief, snel, comfortabel, goedkoop, grote sample size

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14
Q

schatting functioneel lever reserve

A

CHILD-PUGH, MELD, internet

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15
Q

CHILD-PUGH

A

encelophatie graad, hoeveelheid ascites, bilirubine, albumine, PT (INR)

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16
Q

MELD (transplantatie screening)

A

bilirubine, INR, creatinine

17
Q

varices

A

meest levensbedreigende complicatie van portale hypertensie, doodsrisicio gerelateerd aan functioneel reserve

18
Q

behandeling varices

A

control the bleeding, control the portal HTN

19
Q

ascites

A

uiting van advanced cirrose, afgenomen aldosteron door intracellulair volume deficit, centrale doel is Na negatief

20
Q

behandeling ascites

A

dieet restrictie (+diuretica)