Endocrine System Flashcards
Hypothalamus connects to
pituitary gland
Hypothalamus regulates
autonomic nervous system
What is considered the most important part of the endocrine system?
pituitary gland
Pituitary is considered the …
and it…
master gland
is influenced by seasonal changes and/or emotional stress
Pituitary gland secretes…which
endorphins
reduce a person’s sensitivity to pain
Pituitary gland controls
ovulation and works as a catalyst for testes and ovaries to create sex hormones
Parathyroid glands maintain
normal blood levels of calcium and phosphate
Parathyroid hormone increases
reabsorption of calcium and phosphate from bones to blood
Outer portion of adrenal gland
adrenal cortex
Inner portion of adrenal gland
adrenal medulla
Adrenal cortex produces .. that will regulate…
corticosteroids
water and sodium balance, body’s response to stress, the immune system, sexual development and function and metabolism.
Adrenal medulla produces …that will..
epinephrine
increase HR and BP when there is an increase in stress
Where is the pancreas located?
left quadrant of abdominal cavity
Pancreas’s job?
ensure a consistent level of glucose within the bloodstream
Steroid hormones (prostaglandins) are unique in that they..
do not circulate in the blood, but exert their effects only where they are produced.
Effects of steroid hormones
inflammation
pain mechanisms
vasodilation
vasoconstriction
nutrient metabolism
blood clotting
Amine hormones (catecholamines) examples
epinephrine
norepinephrine
dopamine
Amine hormones are where?
adrenal medulla
What releases catecholamines into the blood stream?
sympathetic nervous system stimulation
Where is insulin created?
pancreas
What produces growth hormone-releasing and inhibiting hormone?
And where does it act?
hypothalamus
pituitary
What produces gonadotropin-releasing hormone?
hypothalamus
What produces thyrotropin-releasing hormone?
hypothalamus
What produces corticotropin-releasing hormone?
hypothalamus
What produces prolactin-releasing and inhibiting hormone as well as dopamine?
hypothalamus
What do all the hormones produced by hypothalamus act on?
pituitary
What produces growth hormone?
pituitary
What produces FSH?
Pituitary
What produces LH?
pituitary
What produces TSH?
pituitary
What produces adrenocorticotropic hormone?
pituitary
What produces prolactin?
pituitary
What produces oxytocin?
pituitary
What produces antidiuretic hormone?
pituitary
What does FSH do?
follicular development and creation of estrogen in females and spermatogenesis in males
What does LH do?
ovulation along with estrogen/progesterone synthesis and testosterone in males
What does TSH do?
increases synthesis of T3 and T4
What does prolactin do?
process of lactation
What does oxytocin do?
increases contraction of uterine muscles
promotes release of milk from mammary glands
What hormones are produced by the adrenal cortex?
androgen
aldosterone
cortisol
Androgen
increases masculinization
promotes pubic hair growth
Aldosterone
increases reabsorption of sodium ions by kidneys
increases excretion of potassium ions by kidneys into urine
Cortisol
influences metabolism of food
anti-inflammatory effect in large amounts
Hormones produced by adrenal medulla?
epinephrine and norepinephrine
Epinephrine
increases HR and force of contraction
vasodilation of skeletal muscle
Norepinephrine
vasoconstriction in skin, viscera, and skeletal muscles
Hormones produced by the Pancreas?
glucagon
insulin
When is glucagon produced?
hypoglycemia
When is insulin produced?
hyperglycemia
What hormone is produced by the parathyroid?
parathormone
When is parathormone released?
hypocalcemia
What hormones are produced by the thyroid?
T4 and T3
Calcitonin
T3 and T4
TSH
When is Calcitonin produced?
hypercalcemia
Periarthritis
swelling around joints not in them
Arthralgia
pain in joint
Polydipsia
excessive thirst
Endocrine dysfunction neuromuscular symptoms
muscle weakness
periarthritis
myalgia
arthralgia
stiffness
OA
muscle atrophy
adhesive capsulitis
Endocrine dysfunction systemic symptoms
polydipsia
growth dysfunction
skin pigmentation dysfunction
polyuria
increased vital signs
hair dysfunction
nervousness or anxiety
When there is an endocrine system pathology, it is often which two structures that affect the function of the other endocrine glands?
hypothalamus
pituitary
Hyperfunction of an endocrine gland is usually due to..
overstimulation of pituitary gland
Hypofunction of an endocrine gland is usually due to..
understimulation of pituitary gland
Hypopituitarism
rare
short
delayed growth and puberty
sexual and reproductive disorders
diabetes insipidous
Hyperpituitarism
gigantism
hirsuitism
galactorrhea
amenorrhea
infertility
impotence
Things to consider in rehabbing those with pituitary dysfunction
exercise is encouraged 24 hours surgery
hypoglycemia
bilateral CTS, arthritis, osteophyte formation common with hyperpituitarism
Orthostatic hypotension in hypopituitarism
Bilateral hemianopsia in hypopituitarism
Addisons
hypofunction of adrenal cortex
decreased production of cortisol and aldosterone
Sxs of addisons
hypotension
weakness
anorexia
weight loss
altered pigmentation
left untreated can result in shock and death
Cushings
hyperfunction of adrenal glands
too much cortisol
Sxs of cushings
hyperglycemia
growth failure
truncal obesity
purple abdominal striae
moon shaped face
buffalo hump
weakness
acne
HTN
male gynecomastia
mental changes: depression, poor concentration, memory loss
Considerations for rehabbing those with adrenal dysfunction
recognize signs of stress or exhaustion
notify physician of illness or increased intracranial pressure
orthostatic hypotension-long-term cortisol therapy
report sleep disturbances to doctor
osteoporosis, fracture, degenerative myopathy, tendon ruptures, ataxic gait
delayed wound healing
Postpartum thyroiditis: first 1-4 months what is present?
4-8 months following delivery what does it shift to?
hyperthyroidism
hypothyroidism
Most specific cause of hyperthyroidism?
Graves disease
Graves disease
autoimmune causing thyroid to be overactive
sxs of graves
goiter
heat intolerance
nervousness
weight loss
tremor
palpitations
When rehabbing those with thyroid dysfunction be aware of..
vital signs
effects of radioiodine therapy
risk of rhabdo
Hypoparathyroidism
hypocalcemia
seizures
cognitive defects
short stature
tetany
muscle pain
cramps
Hyperparathyroidism
renal stones
kidney damage
depression
memory loss
muscle wasting
bone deformity
myopathy
Rehab considerations for those with parathyroid dysfunction
be familiar with all signs and symptoms of parathyroid dysfunction in order to refer out
recognize hypercalcemia and hypocalcemia
risk for fractures and effects from osteogenic synovitis
Hypercalcemia occurs from
hyperparathyroidism
Hypocalcemia occurs from
hypoparathyroidism
Osteogenic synovitis affects
achilles
triceps
obturator
tendons
Characteristics of hypoparathyroidism
decreased bone resorption
hypocalcemia
elevated phosphate levels
shortened 4th and 5th metacarpals
compromised breathing due to intercostal muscle and diaphragm spasms
cardiac arrhythmias and potential heart failure
increased neuromuscular activity that can result in tetany
Characteristics of hyperparathyroidism
increased bone resorption
hypercalcemia
decreased phosphate levels
osteitis fibrosa
subperiosteal resorption
arthritis
bone deformity
nephrocalcinosis
renal HTN
significant renal damage
gout
decreased neuromuscular irritability
Hyperglycemia symptoms can occur in what ranges?
What are the symptoms?
> 180-200
occurring in those with type 1 DM
ketoacidosis
dyspnea
fruity breath
dry mouth
nausea
vomiting
confusion
eventual loss of consciousness
Hypoglycemia symptoms can occur at what level?
<70
Etiology of type 1 DM
destruction of islets of Langerhans cells secondary to possible autoimmune or viral factor
ketoacidosis
Etiology of type 2 DM
resistance to insulin receptor sites secondary to obesity
ketoacidosis will rarely occur
After being diagnosed with gestational diabetes and the glucose intolerance lasts more than 6 weeks after childbirth it..
should be reclassified to another form of diabetes
Babies born to those with gestational diabetes have
increased glucose levels
Fasting plasma glucose
8 hours after pts last intake of food or drink
positive if >125
normal is <100
Oral glucose
two hours after ingestion of sugary drink
positive is >200
normal is <140
A1c testing
glucose over 2-3 months
positive if >6.5%
normal is <5.7%
Primary male hypogonadism is
Klenefelter’s syndrome
Primary female hypogonadism is
turner syndrome
Indications for bone mineral regulating agents
Paget’s disease
osteoporosis
hyperparathyroidism
rickets
hypoparathyroidism
osteomalacia
Implications for PT when patients are taking bone mineral regulating agents
risk for fracture