Electrochemical systems of CVS Flashcards

1
Q

What does the neural regulation of cardiovascular system

A

Autonomic nervous system

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2
Q

What do motor neurons do in ANS

A

Innervates smooth muscle, cardiac muscle, internal organs and skin
Makes adjustments to ensure optimal support for body activities

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3
Q

What does motor neuron of ANS have as effector

A

Viscera

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4
Q

What neurotransmitter do somatic motor neurons release in SNS

A

ACh

Has excitatory effect

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5
Q

What neurotransmitter are released in ANS

A

Preganglionic fibres release ACh

Postganglionic fibres release noradrenaline or ACh - effect either stimulators or inhibitory

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6
Q

What is the parasympathetic division

A

Concerned with keeping body energy use low
Largely innervates the internal organs - not he skin
Neurotransmitter = ACh at both ganglionic and effector organs

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7
Q

What is the Sympathetic division

A

Concerned with high energy use
Promotes adjustments during exercise
Innervates every part of the body
Neurotransmitter = ganglionic is ACh, effector organ neurotransmitter is noradrenaline

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8
Q

What is the sinoatrial node

A

Auto rhythmic cells in right atrium near entry of the SVC

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9
Q

What is atrioventricular node

A

Autorhythmic cells near the floor of the right atrium

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10
Q

How are SA and AV nodes connected

A

Internodal pathways through which electrical activity spreads rapidly

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11
Q

Where is the bundle of His

A

Wall of septum between ventricles

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12
Q

What does the bundle of His divide into

A

Left and right branches which continue downwards and divide into many small Purkinje fibres

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13
Q

Which tissue possesses the highest degree of automaticity

A

SA node

Creates impulses at highest frequency and normally suppresses the other elements

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14
Q

What does the p wave represent

A

Atrial depolarisation

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15
Q

What is the QRS complex

A

Ventricular depolarisation

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16
Q

What is the T wave

A

Indicates ventricular repolarisation

17
Q

What is the PR interval

A

Period that shows the delay in AV node

Also represents electrical activity of the atria

18
Q

QT interval

A

Represents electrical activity of the ventricles

19
Q

Phase 0 of SA node

A

Calcium entry
Threshold reached and AP fires
If currents inactive

20
Q

Phase 3 of SA

A

Repolarisation to -60 mV

K+ Current as potassium chsnnels open

21
Q

How does sympathetic (catecholamines) increase heart rate

A

Increases slope of pacemaker potential

Increases rate of depolarisation by increased Ca2+ entry

22
Q

How does parasympathetic (acetylcholine) decrease heart rate

A

Reduces slope of pacemakers potential

Hyperpolarises pacemaker cell membrane via muscadine receptor

23
Q

Difference between SA nodal cell and contractile tissue

A

More negative and stable resting potential

More rapid depolarisation with prominent plateau

24
Q

Phase 0 of cardiac myocyte

A

Depolarisation
AP from SA node opens fast Na+ chennels
Large, but transient, increase in Na+ permeability
Accompanied by dramatic reduction in K+ conductance

25
Q

Phase 1 of cardiac myocyte

A

Early repolarisation
Fast Na+ channels close
Membrane potential begins to fall

26
Q

Phase 2 of cardiac myocyte

A

Plateau
Potential remains positive for ~300 msec
Largely due to opening of voltage-gated slow Ca2+ chennels
Plateau because of Na+ influx from slow Na+ channels and slow leakage of K+ out of the cell keeps potential from rising

27
Q

Phase 3 of cardiac myocyte

A

Repolarisation
Intracellular K+ moves down concentration gradient repolarising cell
Repolarisation facilitated by closure of Ca2+ and slow Na+ channels

28
Q

Phase 4 of cardiac myocyte

A

Resting membrane potential

Cell repolarised and ready for the next stimulus

29
Q

What is advantage of having long refractory period

A

Prevents tetanic contractions
Tetanus can occur in skeletal muscle
Relationship between electrical activity and contraction