Day 10 - HemOnc3

Question 1

Leukemia: most common neoplasm in children

Answer 1

ALL

Question 2

Leukemia: most common neoplasm in adults, avg age of onset 50 yo

Answer 2

CLL

Question 3

Leukemia: Philadelphia chromosome almost always seen

Answer 3

CML

Question 4

Leukemia: Smudge cells on smear

Answer 4

CLL

Question 5

Leukemia: Peripheral blasts, PAS+, TdT+

Answer 5

ALL

Question 6

Leukemia: Peripheral blasts, PAS-, Myeloperoxidase+, Auer rods

Answer 6

AML

Question 7

Leukemia: Pancytopenia in Down syndrome pt

Answer 7

ALL

Question 8

Med assoc w/ remission in 95% of CML pts

Answer 8

Imatinib

Question 9

21 yo p/w recent wt loss, pruritus, night sweats; PE - hepatosplenomegaly, nontender cervical LAD

Answer 9

Hodgkin lymphoma

Question 10

Hematologic neoplasm: Assoc EBV

Answer 10

Burkitt Lymphoma

Question 11

Hematologic neoplasm: Reed-Sternberg cells, cervical LAD, night sweats

Answer 11

Hodgkin lymphoma

Question 12

Hematologic neoplasm: Bence Jones proteins, osteolytic lesions, hypercalcemia

Answer 12

Multiple myeloma

Question 13

Hematologic neoplasm: t(14;18)

Answer 13

Follicular lymphoma

Question 14

Hematologic neoplasm: Most common lymphoma in US

Answer 14

Diffuse large b cell

Question 15

Hematologic neoplasm: t(8;14)

Answer 15

Burkitt lymphoma

Question 16

Hematologic neoplasm: t(9;22)

Answer 16

CML (bcr-abl = Philadelphia chromosome); Also 15% adult ALL

Question 17

Hematologic neoplasm: most common form of Hodgkin lymphoma

Answer 17

Nodular sclerosis

Question 18

Hematologic neoplasm: Starry sky appearance

Answer 18

Due to phagocytosis of apoptotic tumor cells; Burkitt lymphoma

Question 19

Hematologic neoplasm: High Hb & Hct, pruritus (especially after hot shower/bath), burning pain in hands/feet

Answer 19

PCV

Question 20

Hematologic neoplasm: blood smear shows hair like projections, splenomegaly

Answer 20

Hairy B cell leukemia

Question 21

Anti-retrovirals: lactic acidosis

Answer 21

NRTIs

Question 22

Anti-retrovirals: GI intolerance

Answer 22

Protease inhibitors

Question 23

Anti-retrovirals: Pancreatitis, Peripheral neuropathy

Answer 23

Zalcitabine, Stavudine, Didanosine (i.e., certain NRTIs); Ritonavir (protease inhibitor) also causes only pancreatitis

Question 24

Anti-retrovirals: Megaloblastic anemia

Answer 24

Zidovudine (i.e., a NRTI)

Question 25

Anti-retrovirals: Rash

Answer 25

NNRTIs

Question 26

Anti-retrovirals: Hyperglycemia, DM, Lipid abnormalities

Answer 26

Indinavir, Sequinavir, Amprenavir (i.e., certain Protease inhibitors)

Question 27

Anti-retrovirals: Bone marrow suppression

Answer 27

Zidovudine (i.e., a NRTI); recall: also causes megaloblastic anemia

Question 28

Anti-retrovirals: Given to pregnant women w/ HIV

Answer 28

Regardless of HAART therapy, can use Zidovudine(i.e., a NRTI) during labor

Question 29

Anti-retrovirals: Recommended for occupational HIV exposure

Answer 29

Zidovudine + Lamivudine (i.e., certain NRTIs)

Question 30

Antibx ppx in HIV pts: when, with what, & for what organisms

Answer 30

CD4