Day 10 - HemOnc1

Question 1

Characteristic findings of hereditary spherocytosis

Answer 1

Elevated bilirubin: jaundice, gallstones (all hemolytic anemias); Splenomegaly, Anemia w/ reticulocytosis, Increased MCHC; Higher incidence of pseudohyperkalemia; Smear shows spherocytes; Dx w/ positive osmotic fragility test

Question 2

Tx hereditary spherocytosis

Answer 2

Folic acid daily; RBC transfusion if severe anemia; Splenectomy in moderate to severe cases