Day 10 - HemOnc2 Flashcards
DDx eosinophilia
“D-NAACP”: Drugs (NSAIDs, Penicillins), Neoplasm, Atopic (allergies, asthma, ABPA, Churg Strauss), Adrenal insuffiency, Acute interstital nephritis, Collage vascular disease (polyarteritis nodosa, dermatomyositis, etc.), Parasites (Ascara); HyperIgE, Hypereosinophilic syndrome, Coccidiomycoides, etc.
Tx anaphylaxis
ABCs; Stop inciting agent; SubQ Epinephrine (usually in anteriolateral thigh IM); H1 & H2 blockers for cutaneous sx; Albuterol or levalbuterol to reduce airway obstruction, also steroids; IV fluids for hypotension
Drugs causing thrombocytopenia
Heparin, abciximab, carbamazepine, cimetidine, phenytoin, valproate, acyclovir, sulfonamides, rifampin, procainamide, quinine/quinidine, gold compounds
Inherited diseases leading to hypercoagulability - Examples, how generally present, & when to anticoagulate
(1) Factor V Leiden (2) Antithrombin III deficiency (3) Protein C or S deficiency (4) Prothrombin gene mutation (5) Hyperhomocysteinemia; (FYI - Rare disorders include: dysfibrogenemia, plasminogen deficiency); P/w DVT or PE of unknown etiology; Only anticoagulate once they’ve had thrombotic event
Tx for most commonly inherited bleeding disorder
vWD Tx: Desmopressin; Cryoprecipitate, Concentrated Factor VIII for refractory bleeding, OCPs for menorrhagia, Avoid ASA and other platelet inhibitors
Most common causes of DIC
“STOP Making New Thrombi”: Sepsis, Trauma (incl. extensive surgeries), Obstetric complications, Pancreatitis (acute), Malignancy, Nephrotic syndrome, Transfusion
Criteria for SIRS
At least 2 of 4 criteria: (1) Fever (greater than 83C or hypothermia) (2) Tachypnea (3) Tachycardia (4) Leukocytosis/Leukopenia/Bandemia
Tx infectious mononucleosis
No antiviral med (not give acyclovir); NSAIDs/Tylenol for fever, Fluids; Non-contact sports for 4 wks after sx onset; Steroids only helpful if impeding airway due to large tonsils or life threatening (thrombocytopenia, elevated LFTs, hemolytic anemia)
