Day 10 - HemOnc2 Quiz Flashcards
TTP Pentad
Thrombocytopenia, hemolytic anemia, renal failure => uremia (HUS); fever, neuro sx (AMS, seizures, coma)
Most common mutation in white pts predisposing to venous thrombosis
Factor V leiden
Drug mechanism: Streptokinase
thrombolytic (like tPA), cleaves fibrin clots
Drug mechanism: ASA
Inhibits cyclooxygenase, inhibiting platelet aggregation
Drug mechanism: Clopidogrel
ADP receptor blocker
Drug mechanism: Abciximab
GpIIbIIIa inhibitor (like Tirofaban)
Drug mechanism: Ticlopidine
ADP receptor blocker (like clopidogrel)
Drug mechanism: Enoxaparin
LMWH, inhibits factor Xa
Drug mechanism: Eptefibitide
GIIbIIIa inhibitor
Lab test(s) used to monitor: (1) warfarin (2) heparin (3) LMWH
(1) INR (2) PTT (3) Anti-Factor Xa (if needed to be monitored)
Tx vWD
Desmopressin; Severe bleeding - cryoprecipitate or Factor VIII; Menorrhagia - OCPs; Avoid ASA and other platelet inhibitors
Lab changes: HUS/TTP
Low platelet count, Elevated bleeding time, Normal PT/PTT
Lab changes: Hemophilia A/B
Elevated PTT, Normal PT, platelet count and bleeding time
Lab changes: vWD
Normal platelet count, Elevated bleeding time, Normal PT, Elevated PTT
Lab changes: DIC
Platelet count low, Bleeding time high, PT/PTT Elevated
Lab changes: Warfarin use
Normal platelet count and bleeding time, Elevated PT/PTT
Lab changes: End-stage liver disease
Low/Normal platelet count and correlated High/Normal bleeding time; Elevated PT/PTT
Lab changes: ASA use
Normal platelet count, Increased bleeding time; Normal PT/PTT
Criteria for SIRS
2 of 4 following criteria: (1) Fever or Hypothermia (2) Tachypnea (> 20) (3) Tachycardia (>90) (4) Leukopenia (12K)/Bandemia (>10%)
Most important med in anaphylaxis
Epinephrine
Most common causes of DIC
“STOP Making New Thrombi”: Sepsis, Trauma (including extensive surgery), Obstetric complications, Pancreatitis (acute), Malignancy, (Nephrotic syndrome?), Transfusion reactions
