Day 10 - HemOnc2 Quiz

Question 1

TTP Pentad

Answer 1

Thrombocytopenia, hemolytic anemia, renal failure => uremia (HUS); fever, neuro sx (AMS, seizures, coma)

Question 2

Most common mutation in white pts predisposing to venous thrombosis

Answer 2

Factor V leiden

Question 3

Drug mechanism: Streptokinase

Answer 3

thrombolytic (like tPA), cleaves fibrin clots

Question 4

Drug mechanism: ASA

Answer 4

Inhibits cyclooxygenase, inhibiting platelet aggregation

Question 5

Drug mechanism: Clopidogrel

Answer 5

ADP receptor blocker

Question 6

Drug mechanism: Abciximab

Answer 6

GpIIbIIIa inhibitor (like Tirofaban)

Question 7

Drug mechanism: Ticlopidine

Answer 7

ADP receptor blocker (like clopidogrel)

Question 8

Drug mechanism: Enoxaparin

Answer 8

LMWH, inhibits factor Xa

Question 9

Drug mechanism: Eptefibitide

Answer 9

GIIbIIIa inhibitor

Question 10

Lab test(s) used to monitor: (1) warfarin (2) heparin (3) LMWH

Answer 10

(1) INR (2) PTT (3) Anti-Factor Xa (if needed to be monitored)

Question 11

Tx vWD

Answer 11

Desmopressin; Severe bleeding - cryoprecipitate or Factor VIII; Menorrhagia - OCPs; Avoid ASA and other platelet inhibitors

Question 12

Lab changes: HUS/TTP

Answer 12

Low platelet count, Elevated bleeding time, Normal PT/PTT

Question 13

Lab changes: Hemophilia A/B

Answer 13

Elevated PTT, Normal PT, platelet count and bleeding time

Question 14

Lab changes: vWD

Answer 14

Normal platelet count, Elevated bleeding time, Normal PT, Elevated PTT

Question 15

Lab changes: DIC

Answer 15

Platelet count low, Bleeding time high, PT/PTT Elevated

Question 16

Lab changes: Warfarin use

Answer 16

Normal platelet count and bleeding time, Elevated PT/PTT

Question 17

Lab changes: End-stage liver disease

Answer 17

Low/Normal platelet count and correlated High/Normal bleeding time; Elevated PT/PTT

Question 18

Lab changes: ASA use

Answer 18

Normal platelet count, Increased bleeding time; Normal PT/PTT

Question 19

Criteria for SIRS

Answer 19

2 of 4 following criteria: (1) Fever or Hypothermia (2) Tachypnea (> 20) (3) Tachycardia (>90) (4) Leukopenia (12K)/Bandemia (>10%)

Question 20

Most important med in anaphylaxis

Answer 20

Epinephrine

Question 21

Most common causes of DIC

Answer 21

“STOP Making New Thrombi”: Sepsis, Trauma (including extensive surgery), Obstetric complications, Pancreatitis (acute), Malignancy, (Nephrotic syndrome?), Transfusion reactions