cancer 2

Question 1

wilms tumor

Answer 1

most common type of nephroblastoma

Question 2

wilms tumor

peak incidence occurs at ____ and is assoc w ____

Answer 2

2-3 yo

assoc w severe congenital anomalies

Question 3

wilms tumor

manifestations

Answer 3

-painless
-can double in size in 11-13 dy
-hypertension
-hematuria
»>check BUN, creatinine, urinalysis

Question 4

if wilm’s tumor is suspected, then ____ is contraindicated

Answer 4

DO NOT PALPATE

Question 5

wilms tumor nephroblastoma

prognosis

Answer 5

• survival depends on stage

- long term complications incl liver damage

Question 6

wilms tumor

therapy

Answer 6

• postrenal surgery

- chemotherapy phase

Question 7

osteosarcoma

Answer 7

most common tumor affecting skeleton of children

Question 8

osteosarcoma

location

Answer 8

usually in

• metaphysis of distal femur
• proximal tibia
• proximal humerus

Question 9

osteosarcoma tumor is composed of…

Answer 9

immature bone tissue

Question 10

osteosarcoma

what manifestations should be investigated?

Answer 10

deep bone pain causing night awakenings

-should be investigated

Question 11

osteosarcoma

big risk

Answer 11

pulmo metastasis

20% of cases

Question 12

osteosarcoma

therapy

Answer 12

arteriography

• if limb sparing surgery is an option
• chemo after surgery

Question 13

osteosarcoma

chemo after surgery

Answer 13

• most have metastases

- may also need chemo before surgery to shrink the tumor

Question 14

ewing sarcoma

Answer 14

malignant, small, round cell tumor

• usually involved diaphysis of long bones
• can involve any bone

Question 15

ewing sarcoma

chemo is always used after initial tx because…

Answer 15

undetectable metastases are almost always present

Question 16

leukemia

Answer 16

most commonly diagnosed ped malignancy for kids under 14yo

Question 17

leukemia

types

Answer 17

1 acute lymphoblastic leukemia

2 acute myelogenous leukemia

Question 18

acute lymphoblastic leukemia

Answer 18

• 25% of childhood cancers
• 78% of leukemia in kids
• peak onset 2-3 y

Question 19

acute myelogenous leukemia

Answer 19

originates fr myeloid cells

-most common in kids less than 2 yo + in adolescents

Question 20

leukemia

manifestations

Answer 20

• fever
• lethargy
• lymphadenopathy
• large joint or bone pain
• petechiae

Question 21

leukemia

diagnostics

Answer 21

-blood count
-bone marrow aspiration
»»definitve dx procedure

Question 22

leukemia

expected blood count

Answer 22

• anemia
• thrombocytopenia
• neutropenia
• leukemic blasts (immature WBC, lots of bands)

Question 23

hodgkin disease

Answer 23

disorder of lymph system

-usually fr single node or group of nodes

Question 24

hodgkin disease

finding

Answer 24

nontender, firm lymphadenopathy

• usually in supraclavicular + cervical nodes
• occasionally in mediastinal area

Question 25

hodgkin disease

biopsy

Answer 25

reed-sternberg cells

-large, multiple nuclei

Question 26

hodgkin disease

treatment

Answer 26

chemo w 4 drug combo

HSCT if relapse

Question 27

NON hodgkin lymphoma

Answer 27

malignant tumor of lymphoreticular origin

Question 28

NON hodgkin lymphoma

manifestations

Answer 28

• fever
• wt loss
• enlarged lymph glands

Question 29

NON hodgkin lymphoma

therapy

Answer 29

chemo is main tx

Question 30

rhabdomyosarcoma

Answer 30

most common soft tissue tumor dx in kids

-es <5yo

Question 31

rhabdomyosarcoma

manifestations

Answer 31

• swelling
• ptosis
• visual distub
• eye mvmt abnorm

Question 32

rhabdomyosarcoma

therapy

Answer 32

surgical removal of tumor if possible

Question 33

rhabdomyosarcoma mmay have _____ at time of dx

Answer 33

metastasis

Question 34

retinboblastoma

Answer 34

intraocular malignancy of retina

Question 35

retinboblastoma

finding

Answer 35

absent red reflex