alt in hematologic function 2 Flashcards
neutrophil
action
- phagocytic cell
- defends against bacteria
incr neutrophil
incr in bacterl infectn
-infmmtry prcss
eosinophil
action
antigen-antibody rxn
incr/decr eosinophil
I: allergic rxn
D: corticosteroid usage
incr/decr immunoglobulin
I: infectn, allrgc rxn
D: immune deficiency
Severe Combined Immunodeficiency Disease [SCID]
lack of approp functiong B + T cells
Severe Combined Immunodeficiency Disease [SCID]
prognosis
w/o tx, does not survive in 1 yr
Severe Combined Immunodeficiency Disease [SCID]
therapy
hematopoietic stem cell transplantation
Human Immunodeficiency Virus + Acquired Immune Deficiency Syndrome
HIV/AIDS
if fetis is at risk, tx of mom brings infectn rt ro <1%
HIV
etiology
- freq infection d/t poor immune response
- poor nutrition d/t infection, meds
- immune systm overgrowth to compensate
HIV/AIDS
prognosis
asymptomatic at birth
but svlps more severe later symptms faster than adults
HIV/AIDS
diagnosis
repeated testing before dx
-2 neg abx test at >6 mos
to confirm HIV/AIDS dx…
<18 mo: + resulte fr PCR + virus culture
> 18mo: + result fr HIV ELISA + western blood immunoassay
HIV/AIDS
Cat N
not symptomatic
or only 1 symptom fr category A
HIV/AIDS
Cat A
> 2 mild symptom
- lymphadenopathy
- hepatomegaly
- splenomegaly
- recurrent upper resp infectn
- dermatitis
- parotitis
HIV/AIDS
Cat B
moderately symptomatic
- bacterial meningitis
- PNA
- sepsis
- oropharyngeal candidiasis
- cytomegalovirus infectn
HIV/AIDS
Cat C
- cytomegalovirus disease
- kaposi’s sarcoma
- pneumocistis carinii PNA
- toxoplasmosis of brain
HIV/AIDS
antiretroviral med education
- often in combo
- lifelong
HIV/AIDS
medication
- antiretroviral med
- prophylactic sulfamethoxazole-trimethroprim to infants until HIV is excluded
- IVIG for serious infection
systemic lupus erythematosus
sign + main cause of death
-butterfly rash to face
-renal disease main cause of morbidity + mortality
»>benefit fr transplant
systemic lupus erythematosus
treatment
- corticosteroid
- antimalarial med
- NSAIDs
allergic rxn may need…
pre-measured epinephrine in syringe
-w med alert bracelet
