BB EOYS5 Flashcards
Which type of seizure would you not give phenytoin or carbamazepine in order to prevent worsening of symptoms
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you not give phenytoin or carbamazepine in order to prevent worsening of symptoms
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give carbamazepine or lamotrigine as first line treatment?
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give carbamazepine or lamotrigine as first line treatment?
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give sodium valproate as first line treatment? [2]
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give sodium valproate as first line treatment?
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give sodium valproate or ethosuximide as first line treatment?
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which type of seizure would you give sodium valproate or ethosuximide as first line treatment?
Focal seizure
Absence seizure
Generalised Tonic-Clonic Seizures
Atonic Seizures
Myoclonic Seizures
Which anti-epileptic treatment is teratogenic
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam
Which anti-epileptic treatment is teratogenic
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam
Which anti-epileptic treatment works by bind to synaptic vesicle protein SV2A causing a reduction in neurones
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam
Which anti-epileptic treatment works by bind to synaptic vesicle protein SV2A causing a reduction in neurones
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam
Which anti-epileptic treatment would be used to treat status epilepticus
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam
Which anti-epileptic treatment would be used to treat status epilepticus
Sodium Valproate
Ethosuximide
Lamotrigine
Levetiracetam
Lorazepam & Diazepam
Xanthochromia occurs in
Subdural haemorrhage
Epidural haemorrhage
Subarachnoid haemorrhage
Intracerebral haemorrhage
Xanthochromia occurs in
Subdural haemorrhage
Epidural haemorrhage
Subarachnoid haemorrhage
Intracerebral haemorrhage
Which type of hematoma can present with blood in lumbar puncture?
Subdural haemorrhage
Epidural haemorrhage
Subarachnoid haemorrhage
Intracerebral haemorrhage
Which type of hematoma can present with blood in lumbar puncture?
Subdural haemorrhage
Epidural haemorrhage
Subarachnoid haemorrhage
Intracerebral haemorrhage
Which drug can be used as a prophylasix for cluster headaches if used at high dose
nifedipine
diltiazem
amlodipine
verapamil
Which drug can be used as a prophylasix for cluster headaches if used at high dose
nifedipine
diltiazem
amlodipine
verapamil
Which of the following is not used to classify if a headache is a migraine?
Light bothers person (a lot more than without a headache)
Lasts longer than 30mins
Headache limits ability to work or study
Feel nauseated or sick
Which of the following is not used to classify if a headache is a migraine?
Light bothers person (a lot more than without a headache)
Lasts longer than 30mins
Headache limits ability to work or study
Feel nauseated or sick
Triptans bind to which serotonin receptors? [2]
Are triptans agonists or antagonists? [1]
Learn
Agonists of 5-HT1B and 5-HT1D
Ditans bind to which serotonin receptors? [1]
Are they agonists or antagonists [1]
Agonists of 5-HT1F
Ditans are anti-migraine treatment that are agonists at which receptor:
5-HT1B
5-HT1C
5-HT1D
5-HT1E
5-HT1F
Ditans are anti-migraine treatment that are agonists at which receptor:
5-HT1B
5-HT1C
5-HT1D
5-HT1E
5-HT1F
Triptans are anti-migraine treatment that are agonists at which receptors [2]
5-HT1B
5-HT1C
5-HT1D
5-HT1E
5-HT1F
Triptans are anti-migraine treatment that are agonists at which receptors [2]
5-HT1B
5-HT1C
5-HT1D
5-HT1E
5-HT1F
Which anti-epileptics should not be used in absence seizures, as they may exacerbate these types of seizures? [2]
Phenytoin
Carbamazepine
Explain what is meant by phenytoin’s dose dependent / zero order / saturation kinetics characteristics
Most drugs have first order elimination (rate of elimination is proportional to the plasma concentration).
However, with phenytoin, as the dose of drug is increased, because of saturated enzymes, the rate of elimination is no longer proportional to the concentration of drug in the plasma (i.e. there is saturation & so only a finite amount can be eliminated).
When this happens, small increases in drugs can cause large increases in plasma concentration
Antiepileptic drugs:
Name three calcium channels that are used as anti-epileptic drugs [3]
Ethosuximide
Gabapentin / pregabalin (in the PBL)
AEDs
Which drug inhibits GABA metabolism? [1]
Vigabatrin
Status elipeticus is a medical emergency. Name two drugs used to treat this conditon [2]
Lorezepam (IV)
Diazepam (IV)
Alternatives to AEDs
Name 3 surgical procedures that could be used to treat epilepsy [3]
Lobe resection
Corpus callasotomy (reduces propogation of seizures from one cerebral hemisphere to the next)
Functional hemispherectomy
What is the MoA of Levetiracetam? [1]
Binds synaptic vesicle protein SV2A causing a reduction in conduction in neurones
SV2A protein is a part of secretory vesicle membranes that mediates calcium-dependent vesicular neurotransmitter release.
The binding of levetiracetam to SV2A appears to decrease the rate of vesicle release