96 - Solar Urticaria

Question 1

Subforms of chronic inducible urticaria

Answer 1

Physical urticaria
Cholinergic urticaria
Contact urticaria
Aquagenic urticaria

Question 2

Solar urticaria usually is primary, where the cause is unknown. Very rarely, solar urticaria is linked to _____ and is then termed secondary solar urticaria

Answer 2

Cutaneous porphyria

Systemic lupus erythematosus

Question 3

Solar urticaria predominantly affects

Answer 3

Women in the third decade of life

Question 4

Wheals in solar urticaria generally develop within _____ of exposure and disappear usually within _____ of cessation of exposure

Answer 4

A few minutes up to 1 hour

1 hour and after a maximum of 24 hours

Question 5

Solar urticaria typically affects skin areas that are _____ and spares the skin sites that are _____

Answer 5

Normally shielded by clothing

Frequently exposed to light such as the hands and face

Question 6

Characterized by the reoccurrence of light-induced whealing in the same location

Answer 6

Fixed SolU

Question 7

Onset of signs and symptoms after UV exposure is delayed by up to several hours

Answer 7

Delayed SolU

Question 8

Skin mast cell degranulation in SolU is due to exposure of the skin to _____, less commonly _____, and, rarely, _____ radiation

Answer 8

UVA (320 to 400 nm), visible (400 to 600 nm)
UVB (280 to 320 nm)
Infrared (>600 nm)

Question 9

Y/N: The histopathologic features of SolU allow for its distinction from other forms of urticaria

Answer 9

No - do not allow

Question 10

Phototesting is performed by exposing patients to ultraviolet radiation and visible light at skin sites that have been protected from light for several days, most commonly the

Answer 10

Buttocks

Question 11

Threshold testing determines the _____, a marker of disease activity and response to therapy

Answer 11

Minimal urticarial dose

Question 12

Reasons for a negative phototest in patients with SolU

Answer 12

Signs and symptoms limited to erythema in some patients
Prior intake of antihistamines or other medications that inhibit the development of wheals
Refractoriness of the skin due to previous light exposure of the test site

Question 13

Recommended first-line treatment for solar urticaria

Answer 13

Nonsedating H1 antihistamines at standard dose

Question 14

Alpha-MSH analog and melanocortin receptor agonist recently licensed for the treatment of erythropoietic protopophyria
Shown to protect SolU patients from the development of signs and symptoms

Answer 14

Afamelanotide

Question 15

Alpha-MSH analog and melanocortin receptor agonist recently licensed for the treatment of erythropoietic protopophyria
Shown to protect SolU patients from the development of signs and symptoms

Answer 15

Afamelanotide

Question 16

Tolerance to UV light can be achieved by desensitization achieved by

Answer 16

Phototherapy

Question 17

Y/N: Discontinuation of phototherapy, in virtually all patients, results in the loss of protection from light-induced whealing

Answer 17

Yes