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Fitz 9th > 80 - Acne Variants and Acneiform Eruptions > Flashcards

80 - Acne Variants and Acneiform Eruptions Flashcards

1
Q

Neonatal acne can occur in up to _____% of healthy newborns

A

20

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2
Q

Neonatal acne lesions usually appear around _____ of age and resolved spontaneously within _____

A

2 weeks

3 months

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3
Q

_____, a normal commensal on human skin, may also play a role in neonatal acne

A

Malassezia sympodialis

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4
Q

Similar to neonatal acne but with widespread papulopustular lesions over face, scalp, upper chest and back, and shoulders

A

Neonatal cephalic pustulosis

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5
Q

Infantile acne presents at _____ of age classically with open and closed comedones over the cheeks and chin

A

3 to 6 months

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6
Q

Infantile acne is caused in part by the transient elevation of _____ produced by the immature adrenal gland

A

Dehyroepiandrosterone (DHEA)

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7
Q

During the first 6 to 12 months of life, boys may also have an increased level of _____ that stimulates testosterone production

A

Luteinizing hormone

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8
Q

Infantile acne usually resolves around _____ of age

A

1 to 2 years

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9
Q

Mid-childhood acne is defined as appearing between _____ of age

A

1 and 7 years

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10
Q

Severe form of nodular acne

Most common in teenage males

A

Acne conglobata

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11
Q

Also known as acute febrile ulcerative acne

A

Acne fulminans

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12
Q

Sudden appearance of inflammatory, tender oozing, friable plaques with hemorrhagic crusts
Occur primarily in teenage boys

A

Acne fulminans

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13
Q

(Acne conglobata/Acne fulminans):
More explosive
Nodules and polymorphous comedones are less common
Face is not involved as frequently
Neck is usually spared
Ulcerative and crusted lesions are unique
Systemic symptoms are more common

A

Acne fulminans

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14
Q

First-line treatment for acne fulminans

A

Systemic glucocorticoid therapy, along with intralesional glucocorticoids

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15
Q

Has been reportedly beneficial in the treatment acne fulminans associated with erythema nodosum

A

Dapsone in conjunction with isotretinoin

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16
Q

Isotretinoin-induced acne fulminans typically arises within _____ of treatment

A

The first month

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17
Q

SAPHO syndrome

A 
Synovitis
Acne
Pustulosis
Hyperostosis
Osteitis
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18
Q

PAPA syndrome

A

Pyogenic arthritis
Pyoderma gangrenosum
Acne

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19
Q

PASH syndrome

A

Pyoderma gangrenosum
Acne
Hidradenitis suppurativa

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20
Q

PAPASH syndrome

A

Pyogenic arthritis
Acne
Pyoderma gangrenosum
Hidradenitis suppurativa

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21
Q

PAPA, PASH and PAPASH are a group os systemic autoinflammatory disorders resulting from dysregulation of the innate immune system and over production of

A

Interleukin-1

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22
Q

Variant of skin-picking disorder
Quite mild acne is systematically and neurotically excoriated, leaving crusted erosions that may scar
More common in females
Categorized under obsessive-compulsive disorders

A

Acne excoriee

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23
Q

Type of reactions from repetitive physical trauma to the skin: flare in acne with comedones and inflammatory papules

A

Acne mechanica

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24
Q

Type of reactions from repetitive physical trauma to the skin: follicular inflammatory lesions

A

Folliculitis mechanica

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25
Q

Rare and disfiguring variant of acne vulgaris

Woody edema of the mid third face with accompanying erythema and acne

A

Acne with solid facial edema or

Morbihan disease

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26
Q

_____ treatment in acne with solid facial edema is typically ineffective

A

Oral antibiotic

27
Q

PCOS occurs in roughly _____% of women

A

5 to 10

28
Q

PCOS should be suspected in women with any combination of

A

Oligomenorrhea
Clinical or biochemical hyperandrogenism
Polycystic ovaries on ultrasound scan

29
Q

Premenarchal women with acne and hirsutism should be screened for PCOS with

A

Serum free testosterone level

30
Q

Testing for PCOS should be deferred until _____ after menarche

A

2 years

31
Q

Women with PCOS are at increased risk of

A 
Infertility
Impaired glucose tolerance
Type 2 diabetes
Dyslipidemia
Endometrial cancer
Cardiovascular disease
32
Q

Combined _____ can be helpful in controlling acne and hirsutism

A

Oral contraceptives

Spironolactone

33
Q

Autosomal recessive disorder caused by varying enzyme defects in the cortisol production pathway

A

Congenital adrenal hyperplasia

34
Q

21beta-hydroxylase deficiency type:
Screened at birth
Typically present with ambiguous genitalia and salt wasting

A

Classic type

35
Q

21beta-hydroxylase deficiency type:
Can present throughout childhood and adolescence
Normal cortisol levels but increased androgens

A

Nonclassic type

36
Q

Values of _____ in the range of 4000 to 8000 ng/mL are suggestive of CAH

A

Dehydroepiandrosterone

37
Q

Findings of _____ in males are often subtle and acne may be the only sign

A

CAH

38
Q

As early as _____ after initiation of systemic glucocorticoids or corticotropin, folliculitis may appear

A

2 weeks

39
Q

Drug-induced acne can be caused by

A 
Phenytoin
Lithium
Isoniazid
High doses of vitamin B complexes
Halogenated compounds
Certain chemotherapy medications
40
Q

Halogenated compounds containing either bromides or iodides are often found in

A 
Cold and asthma remedies
Sedatives
Radiopaque contrast material
Kelp
Other vitamin and mineral combinations
41
Q

May cause a follicular-based eruption

Primarily used to treat non-small-cell lung cancer, colorectal cancer and breast cancer

A

Epidermal growth factor receptor inhibitors

42
Q

The presence and severity of the acneiform eruption correlates with a (positive/negative) treatment response to EGFR inhibitors

A

Positive

43
Q

Occupational acne caused from chlorinated hydrocarbons

A

Chloracne

44
Q

The lesions of occupational acne are more common on

A

Covered areas with intimate contact to clothing saturated with the offending compound

45
Q

Most common cause of industrial acne

A

Cutting oils

46
Q

Exposure to the dioxin Agent Orange predisposes to

A

Invasive nonmelanoma skin cancer

47
Q

Chlorinated hydrocarbons are found in

A

Fungicides
Insecticides
Wood preservatives

48
Q

Chloracne classically affects the

A 
Malar
Retroauricular
Mandibular
Axillae
Scrotum
49
Q

May occur in patients with preexisting acne vulgaris treated with long-term oral antibiotics, especially the tetracylines
Initial success with oral tetracyclines followed by a worsening of their acne

A

Gram-negative folliculitis

50
Q

Culture of gram-negative folliculitis lesions may reveal _____ in the papulopusutles or _____ in the nodules

A

Enterobacter, Klebsiella, or Escherichia spp.

Proteus spp.

51
Q

Radiation acne begin to appear

A

As the acute phase of radiation dermatitis is resolving

52
Q

Excessive exposure to UV radiation may produce a yellow, atrophic plaque studded with large open comedones

A

Favre-Racouchot syndrome

53
Q

Favre-Racouchot syndrome has also been called

A

Solar comedones
Senile comedones
Nodular cutaneous elastosis with cysts and comedones
Nodular elastoidosis with cysts and comedones

54
Q

In extreme heat, a severe acneiform folliculitis may develop
Major cause of dermatologic disability in military troops serving in tropical climates
Occurs mainly on the trunk and buttocks
Many deep, large, inflammatory nodules with multiple draining areas, resembling acne conglobata

A

Tropical acne

55
Q

Secondary infection with _____ almost always ensues in tropical cane

A

Coagulase-positive staphylococci

56
Q

Multiple, uniform, red, papular lesions seen after sun exposure

A

Acne aestivalis or

Mallorca acne

57
Q

Acne aestivalis is caused by the effects of UV radiation, primarily

A

UVA

58
Q

_____ are ineffective in speeding up the resolution of acne aestivalis

A

Oral antibiotics

59
Q

Preadolescent patients develop comedones, milia, and acneiform red papules within the nasal crease
Can be familial or associated with the “allergic salute”

A

Pseudoacne of the nasal crease

60
Q

Also known as acrocephalosyndactyly
Autosomal dominant disorder marked by the synostoses of the cranium, vertebral bodies and hands and feet
Caused by mutation in the gene encoding FGFR-2
Diffuse acneiform eruption that often involves the arms, buttocks and thighs

A

Apert syndrome

61
Q

Small inflammatory papules and pustules group around the mouth in a typically well demarcated patter, with sparing of the lip margin

A

Perioral dermatitis

62
Q

Small inflammatory papules and pustules group around the mouth in a typically well demarcated patter, with sparing of the lip margin
With involvement of the nose, eyes, or groin region

A

Periorificial dermatitis

63
Q

Severe variant of periorificial dermatitis

Well delineated plaque around the mouth with more likely involvement of the periocular, perinasal, and groin areas

A

Periorificial granulomatous dermatitis

64
Q

Variant of periorificial dermatitis characterized by uniform, granulomatous sarcoidal papules distributed over the typical periorificial areas
Involvement of the upper eyelids and helices of the ears

A

Facial Afro-Caribbean eruption (FACE)

Fitz 9th (108 decks)

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