Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Fitz 9th > 41 - Urticaria and Angioedema > Flashcards

41 - Urticaria and Angioedema Flashcards

1
Q

Local transient skin or mucosal edema and an area of redness that diminish within a day

A

Urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Local and transient skin is mucosal edema that develops in deep tissue mostly without itching but may accompany pain or burning sensations

A

Angioedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Nonacute or chronic urticaria

A

Persist for more than 6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Chronic spontaneous urticaria CS can be divided into

A

With concomitant angioedema
Without angioedema
Recurrent angioedema without wheals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Women have urticaria nearly _____ as often as men do

A

Twice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Edema that involves the superficial portion of the dermis

A

Wheals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Edema that extends into the deep dermis or subcutaneous and submucosal layers

A

Angioedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Y/N: Angioedema may be painful and pruritic

A

No - painful but not pruritic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The heterogeneity of wheals in size and shape is one of the characteristics of

A

Spontaneous urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The duration of individual wheals is long in _____ and shorter in _____

A

Spontaneous urticaria and deep pressure urticaria

Physical urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Angioedema is rare in

A

Physical urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Flowerlike or annular-shaped wheals are characteristic of

A

Spontaneous urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

(Acute/Chronic) spontaneous urticaria tends to be more severe

A

Acute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Most common subtype among the physical urticarias

A

Mechanical urticaria or dermographism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Rare and severe case of symptomatic dermographism with erythematous lines accompanied by punctate wheals characteristic of cholinergic urticaria

A

Cholinergic dermographism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Wheals of symptomatic dermographism may return in the same site or newly develop 3-6 hours after stimulation and persist for up to 48 hours

A

Delayed dermographism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Wheals of symptomatic dermographism may be markedly augmented when the skin is chilled

A

Cold-dependent dermographism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Local skin contact with a cold substance induces wheals and flare

A

Cold contact urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Erythematous edematous and deep swelling may appear 9-18 hours after cold challenge

A

Delayed cold urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Widespread wheals and flare develop in response to cooling of the core body temperature

A

Systemic cold urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Familial cold urticaria syndrome is classified as a subtype of

A

Cryopyrin-associated periodic syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Cryopyrin-associated periodic syndrome is an autosomal dominant inherited disease which is associated with a genetic mutation of

A

NLRP3 (CIASI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Develop wheals and flare that spread in the area of skin exposed to heat, regardless of the core body temperature or sweating

A

Heat urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Y/N: In solar urticaria, face and hands may develop fewer lesions than skin areas that are usually covered by clothes

A

Yes - because of hardening due to chronic exposure to sunlight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Deep dermal wheals that appear in a continuously compressed region

A

Delayed pressure urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Missense mutation of _____ has been reported to be associated with familial vibratory urticaria with autosomal dominant inheritance

A

ADGRE2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Characterized by small wheals, resembling eruption of cholinergic urticaria, but wheals in this urticaria subtype are generally fewer in number compared with eruptions of cholinergic urticaria

A

Aquagenic urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Induced by stimuli that cause sweating and distinctive for its small urticarial eruptions

A

Cholinergic urticaria

29
Q

Pruritus without wheals induced by conditions that elicit sweating

A

Cholinergic pruritus

30
Q

Major antigen in sweat has been identified as _____, a protein produced and released be by _____

A

MGL_1304

Malassezia globosa

31
Q

Oral edema and discomfort induced by contact of the oral mucosa with certain foods

A

Oral allergy syndrome

32
Q

Those with hereditary angioedema do not develop

A

Superficial wheals

33
Q

Most frequent sign of anaphylaxis

A

Wheal and flare

34
Q

Classical type I allergy against exogenous antigens, such as food and drugs, is less than _____% of the whole population of patients with urticaria

A

10

35
Q

Dietary pseudoallergens that may be relevant as a cause or a precipitating or aggravating factor for CSU

A

Salicylates and biogenous amines
Food additives
Topical or oral NSAIDs

36
Q

For a diagnosis of food pseudoallergy, _____ may be followed by well-motivated patients

A

3-week pseudoallergen-free diet

37
Q

The increased sensitivity of patients with CSU to _____ in the diet has been suggested as a cause of nonallergic hypersensitivity

A

Histamine

38
Q

In patients with CSU, especially those with severe symptoms, the levels of _____ are higher than those in healthy control participants

A

Plasma coagulation markers, such as
Prothrombin fragment 1+2 (PF 1+2)
Fibrin degradative products (FDPs)
D-dimer

39
Q

Known to be associated with spontaneous urticaria, especially with the onset of acute urticaria in children and transient aggravation of CSU

A

Acute infections by viruses and bacteria

40
Q

_____, which inhibit cyclooxygenase-1, may induced or aggravate wheals and angioedema

A

Aspirin and other NSAIDs

41
Q

_____ are the most common signs of immediate reactions to contrast media, but delayed nonimmediate reactions may include a _____

A

Erythema and wheals with or without angioedema

Maculopapular rash

42
Q

Drugs that induced histamine release from mast cells or basophils, especially when given at high doses

A 
Opiate analgesics
Polymyxin B
Curare
D-tubocurarine
Vancomycin
43
Q

Drug that does not cause release or production of mediators by themselves but inhibit degradation of bradykinin

A

ACE inhibitors

44
Q

CSU may be associated with

A

Infections

Autoimmune disorders, such as thyroid diseases and collagen diseases

45
Q

Have a higher risk of developing latex allergy

A

Health care workers
Individuals with atopic dermatitis
Patients with spina bifida

46
Q

Flares in disease activity during the evening to early morning is not specific but is a common feature of

A

Spontaneous urticaria

47
Q

Wheals of indictable urticaria do not usually last for more than 4 hours expect

A

Delayed pressure urticaria

48
Q

_____-mediated angioedema does not usually occur in the larynx

A

Mast cell

49
Q

_____-mediated angioedema does not accompany superficial wheals

A

Bradykinin

50
Q

Routine laboratory testing recommended for acute spontaneous urticaria

A

None

51
Q

Routine laboratory testing recommended for chronic spontaneous urticaria

A

CBC

ESR or CRP

52
Q

Hereditary angioedema types

A

I - lack C1-INH protein
II - lack activity of C1-INH because of genetic point mutations
III - normal C1-INH

53
Q

Acquired angioedema may develop by

A

Overconsumption of C1-INH caused by myeloproliferative diseases
Presence of autoantibodies against C1-INH

54
Q

Characterized by urticaria-like eruptions and monoclonal IgM or IgG gammopathy accompanied by systemic syndrome such as fever and bone and muscle pain

A

Schnitzler syndrome

55
Q

Schnitzler syndrome histology resembles

A

Urticarial vasculitis or neutrophilic urticaria

56
Q

Easy and comprehensive method of evaluation for all kinds of urticaria and angioedema

A

Urticaria Control Test

57
Q

Infiltration of neutrophils is prominent especially in

A

Acute urticaria

Physical urticaria

58
Q

Mainstay of treatment for all kinds of mast cell-mediated urticaria

A

Second-generation nonsedating antihistamines

59
Q

Adverse effects of first-generation antihistamines

A

Carry-over effects of sedation in the morning

Paradoxical excitation or possibly epilepsy in children

60
Q

Second-line therapy for intractable cases resistant to standard doses of antihistamines

A

Increased dosing of antihistamines up to fourfold

61
Q

Inhibits circulating IgE and consequently decreases the number of high-affinity Ig E receptor on mast cells and basophils

A

Omalizumab

62
Q

Although it takes 2 months or longer for omalizumab to decrease the number of cell surface high-affinity Ig E receptor, the clinical effect of omalizumab on CST may become apparent within

A

1 week

63
Q

In most cases of _____, antihistamines are not effective

A

Delayed pressure urticaria

Urticarial vasculitis

64
Q

Used for treatment of acute attacks of bradykinin-mediated HAE

A

Icatibant
Ecallantide
Purified or recombinant C1-INH

65
Q

Used for prophylaxis of bradykinin-mediated HAE

A

Purified or recombinant C1-INH
Lanadelumab
BCX7653

66
Q

Y/N: Antihistamines do not cross the plancenta

A

No - cross the placenta

67
Q

Among antihistamine, _____ is often chosen for pregnant women based on its long bioavailability and safety record

A

Chlorphenamine

68
Q

All family members of patients with HAE type I and type II who are older than _____ are recommended to undergo screening

A

1 year old

Fitz 9th (108 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions