37 - Pyoderma Gangrenosum Flashcards
PG most commonly presents as the _____ variant
Classic ulcerative
Up to 70% of reported PG cases are associated with
A known underlying systemic disease
Inflammatory bowel disease Monoclonal gammopathy Hematologic disease Inflammatory arthritis Malignancy Hidradenitis suppurativa
Classification of PG
Ulcerative
Bullous
Pustular
Vegetative
Ulcerative PG most common site of involvement
Leg
Bullous PG is commonly associated with
Hematologic disease
Bullous PG most often appears on
Upper limbs
Generalized eruption that occurs most exclusively in the setting of an exacerbation of acute IBD
Pustular PG or
Pustular eruption of IBD
Gradual on its onset, mild in the discomfort it generates, not usually associated with the presence of systemic disease, and usually more responsive to localized or mild forms of systemic therapy
Vegetative PG
Examples of neutrophilic dermatoses
Sweet syndrome
Behcet diseases
Dermatitis herpetiformis
Neutrophilic eccrine hidradenitis
Neutrophilic dermatoses with a tendency for pathergy
PG
Sweet’s syndrome
Behcet disease
Dermatitis herpetiformis
Components of PAPA syndrome
Pyogenic arthritis
Pyoderma gangrenosum
Acne
PAPA syndrome mutation
Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) or
CD2 antigen-binding protein is (CD2BP1)
Components of PAPASH syndrome
Pyogenic sterile arthritis
PG
Cystic acne
Hidradenitis suppurativa
Components of PASH syndrome
PG
Acne
Hidradenitis suppurativa
Premenstrual flares are associated with
PG
Hidradenitis suppurativa
Acne