37 - Pyoderma Gangrenosum Flashcards

1
Q

PG most commonly presents as the _____ variant

A

Classic ulcerative

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2
Q

Up to 70% of reported PG cases are associated with

A

A known underlying systemic disease

Inflammatory bowel disease
Monoclonal gammopathy
Hematologic disease
Inflammatory arthritis
Malignancy
Hidradenitis suppurativa
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3
Q

Classification of PG

A

Ulcerative
Bullous
Pustular
Vegetative

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4
Q

Ulcerative PG most common site of involvement

A

Leg

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5
Q

Bullous PG is commonly associated with

A

Hematologic disease

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6
Q

Bullous PG most often appears on

A

Upper limbs

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7
Q

Generalized eruption that occurs most exclusively in the setting of an exacerbation of acute IBD

A

Pustular PG or

Pustular eruption of IBD

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8
Q

Gradual on its onset, mild in the discomfort it generates, not usually associated with the presence of systemic disease, and usually more responsive to localized or mild forms of systemic therapy

A

Vegetative PG

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9
Q

Examples of neutrophilic dermatoses

A

Sweet syndrome
Behcet diseases
Dermatitis herpetiformis
Neutrophilic eccrine hidradenitis

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10
Q

Neutrophilic dermatoses with a tendency for pathergy

A

PG
Sweet’s syndrome
Behcet disease
Dermatitis herpetiformis

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11
Q

Components of PAPA syndrome

A

Pyogenic arthritis
Pyoderma gangrenosum
Acne

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12
Q

PAPA syndrome mutation

A

Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) or
CD2 antigen-binding protein is (CD2BP1)

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13
Q

Components of PAPASH syndrome

A

Pyogenic sterile arthritis
PG
Cystic acne
Hidradenitis suppurativa

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14
Q

Components of PASH syndrome

A

PG
Acne
Hidradenitis suppurativa

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15
Q

Premenstrual flares are associated with

A

PG
Hidradenitis suppurativa
Acne

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16
Q

(Positive/Negative) role of estrogen and a (positive/negative) role of androgen in cutaneous wound healing

A

Positive

Negative

17
Q

Y/N: Patients with classic ulcerative PG who are older than 65 years of age and male patients seem to have a worse prognosis.

A

Yes

18
Q

Vegetative PG is associated with

A

Chronic renal impairment

19
Q

First line agents for severe PG

A

Prednisone

Cyclosporine