37 - Pyoderma Gangrenosum

Question 1

PG most commonly presents as the _____ variant

Answer 1

Classic ulcerative

Question 2

Up to 70% of reported PG cases are associated with

Answer 2

A known underlying systemic disease

Inflammatory bowel disease
Monoclonal gammopathy
Hematologic disease
Inflammatory arthritis
Malignancy
Hidradenitis suppurativa

Question 3

Classification of PG

Answer 3

Ulcerative
Bullous
Pustular
Vegetative

Question 4

Ulcerative PG most common site of involvement

Answer 4

Leg

Question 5

Bullous PG is commonly associated with

Answer 5

Hematologic disease

Question 6

Bullous PG most often appears on

Answer 6

Upper limbs

Question 7

Generalized eruption that occurs most exclusively in the setting of an exacerbation of acute IBD

Answer 7

Pustular PG or

Pustular eruption of IBD

Question 8

Gradual on its onset, mild in the discomfort it generates, not usually associated with the presence of systemic disease, and usually more responsive to localized or mild forms of systemic therapy

Answer 8

Vegetative PG

Question 9

Examples of neutrophilic dermatoses

Answer 9

Sweet syndrome
Behcet diseases
Dermatitis herpetiformis
Neutrophilic eccrine hidradenitis

Question 10

Neutrophilic dermatoses with a tendency for pathergy

Answer 10

PG
Sweet’s syndrome
Behcet disease
Dermatitis herpetiformis

Question 11

Components of PAPA syndrome

Answer 11

Pyogenic arthritis
Pyoderma gangrenosum
Acne

Question 12

PAPA syndrome mutation

Answer 12

Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) or
CD2 antigen-binding protein is (CD2BP1)

Question 13

Components of PAPASH syndrome

Answer 13

Pyogenic sterile arthritis
PG
Cystic acne
Hidradenitis suppurativa

Question 14

Components of PASH syndrome

Answer 14

PG
Acne
Hidradenitis suppurativa

Question 15

Premenstrual flares are associated with

Answer 15

PG
Hidradenitis suppurativa
Acne

Question 16

(Positive/Negative) role of estrogen and a (positive/negative) role of androgen in cutaneous wound healing

Answer 16

Positive

Negative

Question 17

Y/N: Patients with classic ulcerative PG who are older than 65 years of age and male patients seem to have a worse prognosis.

Answer 17

Yes

Question 18

Vegetative PG is associated with

Answer 18

Chronic renal impairment

Question 19

First line agents for severe PG

Answer 19

Prednisone

Cyclosporine