54 - Bullous Pemphigoid

Question 1

Most common autoimmune blistering disorder in the adult population

Answer 1

BP

Question 2

BP: autoantibodies directed against

Answer 2

Hemidesmosomal proteins BP180 and BP230

Question 3

Lesions of BP are most commonly found on

Answer 3

Flexural surfaces
Lower abdomen
Thighs

Question 4

Y/N: Pruritus is usually minimal in BP

Answer 4

No - intense

Question 5

Mucous membrane lesions occur in approximately _____% of patients and are almost always limited to the _____

Answer 5

10

Oral mucosa

Question 6

The presence of scarring or mucosal predominant disease in the absence of classic cutaneous findings is more suggestive of

Answer 6

Mucous membrane pemphigoid

Question 7

BP may also coexist with other cutaneous diseases, notably

Answer 7

Lichen planus

Question 8

Describes the coexistence of BP and lichen planus

Answer 8

Lichen planus pemphigoides

Question 9

Lichen planus pemphigoides has a (less/more) severe clinical course compared with classic BP

Answer 9

Less

Question 10

Approximately 75% of patients have elevated total serum _____ levels, which often correlates with titers of BP IgG antibodies by IF

Answer 10

IgE

Question 11

Harbors the major autoantibody-reactive epitopes

Answer 11

BP180 NC16A domain

Question 12

Correlate well with disease activity

Answer 12

Serum levels of anti-BP180-NC16A IgG

Question 13

_____ disease is frequently seen in BP patients

Answer 13

Neurologic