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Fitz 9th > 108 - Benign Epithelial Tumors, Hamartomas, and Hyperplasias > Flashcards

108 - Benign Epithelial Tumors, Hamartomas, and Hyperplasias Flashcards

1
Q

Most common acquired benign epithelial tumor of the skin

A

Seborrheic keratoses

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2
Q

Most common malignancy associated with Leser-Trelat sign

A

Gastrointestinal

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3
Q

Second most common malignancy associated with Leser-Trelat sign

A

Lymphoproliferative disease

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4
Q

Pseudo-sign of Leser-Trelat may be caused by

A

Chemotherapeutic agents, such as cytarabine - may cause inflammation of preexisting SKs, which then become more clinically apparent

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5
Q

Most frequently detected in SK are activating mutations in

A

FGFR3

PIK3CA

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6
Q

Clinicopathologic variants of SK

A 
Common SK
Reticulated SK
Stucco ketatosis
Melanoacanthoma
DPN
Polypoid SK
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7
Q

Histologic variants of SK

A

Clonal SK
Irritated SK
Malignant transformation or collision lesions

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8
Q

SK lesions wtih surrounding eczematous changes

A

Meyerson phenomenon

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9
Q

An association with _____ has been suggested in lichen striatus

A

Atopic dermatitis

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10
Q

The eruption of lichen striatus is self-limited, with spontaneous regression with

A

A few months to 2 years

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11
Q

In lichen striatus, there may be a dermal lymphocytic infiltrate in a perivascular and periadnexal pattern, with characterstic accentuation around

A

Eccrine coils

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12
Q

Predilection site of clear cell acanthoma

A

Lower legs of middle-aged to older individuals

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13
Q

Solitary, shiny, erythematous to brown, well-demarcater papule or nodule that blanched almost fully with pressure
Surrounding collarette of scale

A

Clear cel acanthoma

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14
Q

Clear cell acanthoma show dermoscopic features similar to

A

Psoriasis

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15
Q

Keratinocyte pallor in clear cell acanthoma is because of heavy cytoplasmic glycogen, as evidenced by _____ positivity

A

Periodic acid-Schiff

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16
Q

Chronic tender nodule thay develops most commonly on the helix of the ear in men older than 50 years of age

A

Chondrodermatitis nodularis helicis

17
Q

Skin-colored, umbilicated papule on the head or neck of middle-aged and older individuals
Histology: cup-shaped epidermal invagination with acantholysis and dyskeratosis filled with keratinaceous plug

A

Warty dyskeratoma

18
Q

Fissured or ulcerated, firm, fresh-colored nodule, usually retroauricular, that appears in areas of friction, as with ill-fitting eyeglasses

A

Acanthoma fissuratum/granuloma fissuratum

19
Q

Most common variant of epidermal nevi

A

Keratinocytic epidermal nevus

20
Q

Unilateral subtype of keratinocytic epidermal nevi

A

Nevus unius lateris

21
Q

Bilateral subtype of keratinocytic epidermal nevi

A

Ichthyosis hystrix

22
Q

Hairless, yellow, waxy and verrucous plaques following a blaschkoid pattern most commonly on the scalp

A

Nevus sebaceous

23
Q

Schimmelpening syndrome is also called

A

Nevus sebaceous syndrome

24
Q

After puberty, nevus sebaceous become (less/more) thickened and verrucous because of hormonal influences

A

More

25
Q

Most common tumors found within nevus sebaceous

A 
Trichoblastoma (7%)
Syringocystadenoma papilliferum (5%)
26
Q

The risk for developing true BCC in nevus sebaceous is currently believed to be closer to _____%

A

1

27
Q

Nevus comedonicus syndrome is the association of nevus comedonicus with noncutaneous findings such as

A

Skeletal defects
Cerebral abnormalities
Cataracts

(SCC)

28
Q

Most common extracutaneous anomalied associated with epidermal nevus syndrome

A

Ocular
Neurologic
Skeletal

29
Q

Segmental smooth muscle hamartoma in association with musculoskeletal defects such as ipsilateral breast hypoplasia

A

Becker nevus syndrome

30
Q

Epidermal hamartoma with long, fine white hair in addition to ocular, neurologic, and skeletal deficiencies

A

Angora hair nevus syndrome

31
Q

Genetic disorders that may predispose individuals to having epidermoid cysts

A 
Gorlin syndrome (nevoid BCC syndrome)
Pachyonychia congenita type 2 (Jackson-Lawler type)
Gardner syndrome
32
Q

Arise from the epithelium located between the orifice of the sebaceous glabd and the arrector pili muscle

A

Trichilemmal cyst

33
Q

Trichilemmal cysts arise from the

A

Outer root sheath

34
Q

Steatocystoma multiplex can be found in syndromes such as

A

Alagille syndrome

Pachyonychia congenita type II

35
Q

Lined with epitheliun containing a lymphocytic infiltrate and lymphoid follicles are common

A

Brachial cyst

Fitz 9th (108 decks)

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