114 - Paget's Disease Flashcards
Y/N: Mammary Paget’s disease is typically associated with an underlying breast mass
Yes
Y/N: Most cases of EMPD are not associated with an underlying adnexal carcinoma or visceral malignancy
Yes
Most commonly affected area in EMPD
Vulva
Theories in the pathogenesis of Paget’s disease
Epidermotropic theory
Transformation theory
In the _____ theory, malignant Paget cells arise from an underlying breast carcinoma and directly extend into the epidermis via the lactiferous ducts and ductules
Epidermotropic
The _____ theory suggests that epidermal keratinocytes on the nipple transform or degenerate into malignant Paget cells
Transformation
The literature currently favors the _____ theory
Epidermotropic
Y/N: Paget cells have intracellular mucopolysaccharides, with MPD having a greater amount of mucin compared to EMPD
No - EMPD having a greater amount of mucin compared to MPD
Sensitive markers for both MPD and EMPD as they stain Paget cells but do not typically react with epidermal or mucosal keratinocytes
CK7
CAM 5.2
HER2/neu is more often positive in
MPD
Than in EMPD
CK20 positivity has been found more frequently in cases of
Secondary EMPD with underlying carcinoma
As compared to cases of primary EMPD
Marker for apocrine epithelium
More commonly positive in primary EMPD and negative in cases of secondary EMPD with an associated malignancy
GCDFP-15
Mucin core protein (MUC) _____ positivity is noted in both MPD and EMPD
1
Mucin core protein (MUC) _____ expression is generally negative in primary EMPD but may be expressed in cases of secondary EMPD with an associated underlying colorectal adenocarcinoma
2
Mucin core protein (MUC) _____ is more frequently positive in invasive and metastatic EMPD than in noninvasive EMPD
5AC
