9 - INNATE 6

Question 1

where do ILCs tend to reside

Answer 1

different inducing cytokines lead to differentiation into different ILCs, which secrete different cytokines

Question 2

where do NK cells reside

Answer 2

Question 3

which lineage do ILCs and NK cells come from

Answer 3

they share the common lymphoid progenitor with B and T cells

Question 4

which types of cells have PRRs

Answer 4

ILCs do not have PRRs

Question 5

how are innate lymphoid cells (ILCs) activated if they do not have PRRs?

Answer 5

Question 6

what can receptors for self proteins on NK cells be induced by

Answer 6

infections
malignant transformations (cancer)
other stresses

Question 7

what can activated NK cells do

Answer 7

Question 8

characteristics of NK cell receptors

Answer 8

Question 9

what happens on NK cells in a normal context

Answer 9

Question 10

what happens on NK cells in a disease context

Answer 10

the granules can create holes in the target cells, which will lead to cell death

Question 11

what is another way that NK cells can trigger apoptosis

Answer 11

TRAIL=death receptor
granules are not secreted, but instead there is intracellular signaling in the target cells, and caspase 8 is activated, which will kill the cell
the target cell programs its own cell death