13 - LINKING 4 Flashcards
what kind of antigen processing does class I presentation require
requires cytosolic or endogenous processing
what kind of antigen processing does class II presentation require
requires exogenous processing
how are peptides generated in the endogenous pathway
polyubiquitination serves as signal for recognition by proteasomes
polyub proteins are fed into the proteasome and degraded
bound by the 19S cap
diagram of endogenous processing
what is the first step of endogenous processing
what is the second step of endogenous processing
what is the third step of endogenous processing
what is the fourth step of endogenous processing
how is the entry of exogenous pathogens mediated
how is the entry of endogenous pathogens mediated
how are peptides generated in the exogenous pathway
diagram of how peptides are generated in the exogenous pathway (MHC II)
where is the MHC-II formed
formed in the ER
what does the invariant (li) chain do
how is li made into Clip
diagram of peptide loading onto MHCII
what is the first step of peptide loading onto MHCII
what is the second step of peptide loading onto MHCII
what is the third step of peptide loading onto MHCII
what is the fourth step of peptide loading onto MHCII
summary
diagram of the entire thing side by side
