16 - LINKING 7 Flashcards
1
Q
what does IL-2 induce?
A
2
Q
which genes do those signals activate the transcription of
A
IL-2 gene (the cytokine)
IL-2Ralpha gene (aka CD25) (part of the receptor)
IL-2Ralpha is not expressed at the baseline
these genes are different and regulated differently
2
Q
reminder: what are signals 1 and 2 of T-cell activation
A
signal 1: TCR
signal 2: CD28
3
Q
what is the effect of activating the transcription of IL-2Ralpha
A
4
Q
summary of the functions of naive vs T cell that received signals 1 and 2
A
5
Q
what other cells does IL-2 also affect
A
6
Q
summary
A
7
Q
summary of the module
A
