15 - LINKING 6 Flashcards
1
Q
what are the three signals that activate T cells
A
2
Q
what are the two types of receptors in signaling
A
3
Q
which domains recognise phosphorylated tyrosines
A
4
Q
how does TCR binding initiate signaling
A
involves the TCR complex:
- TCR
- ITAM domains (immunoreceptor tyrosine based activation motifs)
- CD3
- zeta chains
it is really the co-receptor that initiates the first signal
5
Q
what is the order of TCR signaling and the complex
A
6
Q
take home messages of signal 1
A
7
Q
what is required for T cell activation survival and proliferation
A
costimulation
8
Q
what are some costimulatory ligands and receptors
A
9
Q
what are some positive and negative costimulatory receptors
A
10
Q
CD28 receptor characteristics
A
11
Q
how does CD28 signaling work
A
12
Q
what happens to T cells in the absence of costimulation
A
13
Q
summary
A
