19 - T CELL 2 Flashcards
characteristics of the Fas and CD40 ligand
on which cells is Fas expressed and what is it used for
on which cells is CD40 expressed and what is it used for
characteristics of CD8+ T cells
what are the two ways in which CD8+ T cells can be activated to become cytotoxic effector cells
how does sequential CD8+ activation happen
DC cell activates helper cell, gets the license to activate a CD8+ cell
this happens one after the other
the licensing is CD40 ligand to CD40 binding
IL-2 acts in autocrine fashion
how does simultaneous CD8+ activation happen
IL-2 acts in paracrine fashion
IL-2 and CD40 actions in sequential and simultaneous activation (wink wink nudge nudge)
what needs to happen to CD4+ T cells in order for CD8+ activation to happen
how are CD4+ T cells activated and how do they provide the license to the APC
how do CTLs (cytotoxic T lymphocytes) look for their targets
they travel to the side of infection and can kill infected cells in the periphery
when the CTL recognises the pMHC (infected/cancerous cell) that cell dies
what are the functions of effector CTLs
how does Fas-FasL mediated killing work
how does granule mediated killing work
what are the proteins of the granules of CTLs (cytotoxins) and their actions on target cells
perforin is a pore forming proteins
punches holes in the membranes
take home messages
what do perforin/granzyme pathways and Fas/FasL pathways converge to?
converge on various caspase 3 activation leading to apoptosis
summary
